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ASAH2 抗体 (C-Term)

ASAH2 适用: 人, 小鼠, 大鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6990954
发货至: 中国
  • 抗原 See all ASAH2 抗体
    ASAH2 (N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2))
    抗原表位
    • 8
    • 8
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    C-Term
    适用
    人, 小鼠, 大鼠
    宿主
    • 33
    • 1
    克隆类型
    • 34
    多克隆
    标记
    • 11
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This ASAH2 antibody is un-conjugated
    应用范围
    • 20
    • 19
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB), ELISA
    纯化方法
    ASAH2 Antibody is affinity chromatography purified via peptide column.
    免疫原
    ASAH2 antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human ASAH2. The immunogen is located within the last 50 amino acids of ASAH2.
    亚型
    IgG
    Top Product
    Discover our top product ASAH2 Primary Antibody
  • 应用备注
    ASAH2 antibody can be used for detection of ASAH2 by Western blot at 1 and 2 μ,g/mL.

    Antibody validated: Western Blot in human samples. All other applications and species not yet tested.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    ASAH2 Antibody is supplied in PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,4 °C
    储存方法
    ASAH2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • 抗原
    ASAH2 (N-Acylsphingosine Amidohydrolase (Non-Lysosomal Ceramidase) 2 (ASAH2))
    别名
    ASAH2 (ASAH2 产品)
    别名
    BCDase antibody, HNAC1 antibody, LCDase antibody, N-CDase antibody, NCDase antibody, AI585898 antibody, N-acylsphingosine amidohydrolase 2 antibody, ASAH2 antibody, Asah2 antibody
    背景
    ASAH2 Antibody: Sphingolipids are hydrolyzed by ceramidases to yield sphingosine and fatty acids. These ceramidases are classified according to the pH range that supports their optimal activity. ASAH2 is a neutral ceramidase and key regulator of sphingolipid signaling metabolites at the cell surface, catalyzing the hydrolysis of the N-acyl linkage of ceramide at an optimal pH of 6.5-8.5. ASAH2 is a type II integral membrane protein that can be cleaved to yield a soluble secreted protein and acts as a repressor of apoptosis both by reducing C16-ceramide, thereby preventing ceramide-induced apoptosis, and generating sphingosine. Sphingosine exerts both mitogenic and apoptosis-inducing activities, and its phosphorylated form functions as an intra- and intercellular second messenger. ASAH2 is ubiquitously expressed primarily expressed with higher levels in the intestine, kidney, skeletal muscle and heart. Recent studies indicate that ASAH2 encoded neutral ceramidase is a key enzyme for the catabolism of dietary sphingolipids and regulates the levels of bioactive sphingolipid metabolites in the intestinal tract.
    基因ID
    56624
    NCBI登录号
    NP_063946
    UniProt
    Q9NR71
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