Anthrax Toxin Lethal Factor 抗体 (AA 420-470)
Lef
适用: Bacillus anthracis
ELISA
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all Anthrax Toxin Lethal Factor (Lef) products
- Anthrax Toxin Lethal Factor (Lef)
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抗原表位
- AA 420-470
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适用
- Bacillus anthracis
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This Anthrax Toxin Lethal Factor antibody is un-conjugated
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应用范围
- ELISA
- 纯化方法
- Anthrax Lethal Factor Antibody is affinity chromatography purified via peptide column.
- 免疫原
- Anthrax lethal factor antibody was raised against a synthetic peptide corresponding to 16 amino acids in the middle of the Anthrax lethal factor protein. The immunogen is located within amino acids 420 - 470 of Anthrax Lethal Factor.
- 亚型
- IgG
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anti-Anthrax Toxin Lethal Factor (Lef) (AA 779-792) antibody
Lef 适用: Bacillus anthracis WB 宿主: 小鼠 Monoclonal unconjugated
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- 应用备注
- Anthrax lethal factor antibody can be used for the detection of Anthrax LF protein in ELISA. It will detect 10 ng of free peptide at 1 μ,g/mL.
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- Anthrax Lethal Factor Antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- Anthrax Lethal Factor antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- Anthrax Toxin Lethal Factor (Lef)
- 别名
- Anthrax Lethal Factor (Lef 产品)
- 别名
- pXO1-107 antibody, pxo1_107 antibody
- 背景
- Anthrax Lethal Factor Antibody: Anthrax infection is initiated by the inhalation, ingestion, or cutaneous contact with Bacillus anthracis endospores. B. anthracis produces three polypeptides that comprise the anthrax toxin: protective antigen (PA), lethal factor (LF), and edema factor (EF). PA binds to two related proteins on the cell surface, these are termed tumor epithelial marker 8 (TEM8)/anthrax toxin receptor (ATR) and capillary morphogenesis protein 2 (CMG2), although it is still unclear which is physiologically relevant. Following PA binding to its receptor, PA is cleaved into two fragments by a furin-like protease. The bound fragment binds both LF and EF, the resulting complex is then endocytosed which allows the translocation of LF and EF into the cytoplasm. LF is the primary toxin of anthrax and functions as a highly specific protease that cleaves members of the mitogen-activated protein kinase kinase (MAPKK) family near their amino terminus, interfering with MAPK signaling and inducing apoptosis.
- 基因ID
- 3361711
- UniProt
- P15917
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