SIGIRR 抗体 (C-Term)
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- 抗原 See all SIGIRR 抗体
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
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抗原表位
- C-Term
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适用
- 人, 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This SIGIRR antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunocytochemistry (ICC), ELISA
- 纯化方法
- SIGIRR Antibody is affinity chromatography purified via peptide column.
- 免疫原
- SIGIRR antibody was raised against a synthetic peptide corresponding to 15 amino acids at the C-terminus of human SIGIRR. The immunogen is located within the last 50 amino acids of SIGIRR.
- 亚型
- IgG
- Top Product
- Discover our top product SIGIRR Primary Antibody
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anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-118) antibody
SIGIRR 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-118) antibodySIGIRR 适用: 大鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-120) antibodySIGIRR 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-410) antibodySIGIRR 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-410) antibodySIGIRR 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 3H8-2G3 unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (C-Term) antibodySIGIRR 适用: 人, 小鼠, 大鼠, 马, 斑马鱼, Cow, 犬, 豚鼠, 猴 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (C-Term) antibodySIGIRR 适用: 人, 小鼠, 大鼠, 马, 斑马鱼, Cow, 犬, 豚鼠, Pig WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (C-Term) antibodySIGIRR 适用: 人, 小鼠 WB, IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 1-117) antibodySIGIRR 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR) (AA 334-358) antibodySIGIRR 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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SIGIRR antibody can be used for the detection of SIGIRR by Western blot at 1 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 10 μ,g/mL.
Antibody validated: Western Blot in human samples and Immunocytochemistry in human samples. All other applications and species not yet tested. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- SIGIRR Antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- SIGIRR antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- SIGIRR (Single Immunoglobulin and Toll-Interleukin 1 Receptor (TIR) Domain (SIGIRR))
- 别名
- SIGIRR (SIGIRR 产品)
- 别名
- TIR8 antibody, AI256711 antibody, sc:d148 antibody, RGD1306732 antibody, single Ig and TIR domain containing antibody, single immunoglobulin and toll-interleukin 1 receptor (TIR) domain antibody, SIGIRR antibody, Sigirr antibody, sigirr antibody
- 背景
- SIGIRR Antibody: SIGIRR is a member of the Toll-like receptor-interleukin 1 receptor superfamily. Members of this family are defined by the presence of an intracellular Toll-IL-1R (TIR) domain. The Toll-like receptors (TLRs) are signaling molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. SIGIRR was originally identified through database analysis and was shown to have only one Ig domain as opposed to the normal three Ig folds seen in the TIR family. Similar to ST2, another TIR family member, it has been shown to negatively regulate IL-1 receptor and Toll-like receptor signaling. However, SIGIRR inhibits TLR-IL-1R signaling by dimerizing with TLR4, TLR5, TLR9, and IL-1R. It also associates with the down-stream TLR signaling proteins IRAK and TRAF6 in an IL-1-dependent fashion.
- 分子量
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Predicted: 45 kDa
Observed: 45 kDa - 基因ID
- 59307
- UniProt
- Q6IA17
- 途径
- Toll-Like Receptors Cascades
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