BIRC2 抗体 (C-Term)
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- 抗原 See all BIRC2 抗体
- BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))
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抗原表位
- AA 540-590, C-Term
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This BIRC2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 纯化方法
- cIAP Antibody is affinity chromatography purified via peptide column.
- 免疫原
- Anti-cIAP antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human cIAP. c-IAP antibody detects both c-IAP1 and c-IAP2. The immunogen is located within amino acids 540-590 of cIAP.
- 亚型
- IgG
- Top Product
- Discover our top product BIRC2 Primary Antibody
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anti-Baculoviral IAP Repeat Containing 2 (BIRC2) (AA 1-300) antibody
BIRC2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 2 (BIRC2) (C-Term) antibodyBIRC2 适用: 人, 小鼠, 大鼠 WB, IHC, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 2 (BIRC2) (AA 1-618) antibodyBIRC2 适用: 人 WB, PLA 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 2 (BIRC2) (AA 344-593) antibodyBIRC2 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 2 (BIRC2) (AA 148-298) antibodyBIRC2 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-Baculoviral IAP Repeat Containing 2 (BIRC2) (C-Term) antibodyBIRC2 适用: 人, 小鼠 WB, IHC (p), EIA 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB: 1-4 μ,g/mL, IHC: 10 μ,g/mL, IF: 20 μ,g/mL.
Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in human samples, Immunofluorescence in human samples. All other applications and species not yet tested. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- cIAP Antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- cIAP antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- BIRC2 (Baculoviral IAP Repeat Containing 2 (BIRC2))
- 别名
- cIAP (BIRC2 产品)
- 背景
- CIAP Antibody: Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The two isoforms of c-IAP (c-IAP1 and c-IAP2) are structurally related to XIAP, containing 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases-3, -7. The c-IAPs can associate with the death receptor TNF-R2, and mediate the ubiquitinization of TRAF2 following the binding of TNF-α, by its receptor. Omi, a negative regulator of c-IAP, inhibits its activity by catalytically cleaving c-IAP. Another negative regulator, Smac/DIABLO, acts by enhancing the auto-ubiquitization activity of c-IAP.
- 分子量
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Predicted: 70kD
Observed: 70kD kDa - 基因ID
- 329
- NCBI登录号
- NP_001157
- UniProt
- Q13490
- 途径
- Apoptosis, Caspase Cascade in Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades
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