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PHAP I 抗体 (C-Term)

适用: 人, 小鼠, 大鼠 WB, ELISA, IF, IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6990427
发货至: 中国
  • 抗原 See all PHAP I products
    PHAP I
    抗原表位
    C-Term
    适用
    人, 小鼠, 大鼠
    宿主
    • 1
    克隆类型
    • 1
    多克隆
    标记
    • 1
    This PHAP I antibody is un-conjugated
    应用范围
    Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    特异性
    This polyclonal antibody has no cross-reaction to PHAP I2a and PHAP III.
    纯化方法
    PHAP I Antibody is affinity chromatography purified via peptide column.
    免疫原
    Anti-PHAP I antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human PHAP I . The immunogen is located within the last 50 amino acids of PHAP I.
    亚型
    IgG
  • 应用备注
    WB: 1 μ,g/mL, IHC: 2 μ,g/mL, IF: 20 μ,g/mL.

    Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in mouse samples, Immunofluorescence in mouse samples. All other applications and species not yet tested.
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 mg/mL
    缓冲液
    PHAP I Antibody is supplied in PBS containing 0.02 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,4 °C
    储存方法
    PHAP I antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
  • 抗原
    PHAP I
    Abstract
    PHAP I 产品
    背景
    PHAP I Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
    分子量
    Predicted: 29kD

    Observed: 29 kD kDa
    基因ID
    8125
    UniProt
    P39687
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