PHAP I 抗体 (C-Term)
适用: 人, 小鼠, 大鼠
WB, ELISA, IF, IHC (p)
宿主: 兔
Polyclonal
unconjugated
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- 抗原 See all PHAP I products
- PHAP I
- 抗原表位
- C-Term
- 适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PHAP I antibody is un-conjugated
- 应用范围
- Western Blotting (WB), ELISA, Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 特异性
- This polyclonal antibody has no cross-reaction to PHAP I2a and PHAP III.
- 纯化方法
- PHAP I Antibody is affinity chromatography purified via peptide column.
- 免疫原
- Anti-PHAP I antibody was raised against a peptide corresponding to 14 amino acids near the carboxy terminus of human PHAP I . The immunogen is located within the last 50 amino acids of PHAP I.
- 亚型
- IgG
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- 应用备注
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WB: 1 μ,g/mL, IHC: 2 μ,g/mL, IF: 20 μ,g/mL.
Antibody validated: Western Blot in human, mouse and rat samples, Immunohistochemistry in mouse samples, Immunofluorescence in mouse samples. All other applications and species not yet tested. - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 mg/mL
- 缓冲液
- PHAP I Antibody is supplied in PBS containing 0.02 % sodium azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,4 °C
- 储存方法
- PHAP I antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
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- 抗原
- PHAP I
- Abstract
- PHAP I 产品
- 背景
- PHAP I Antibody: Apoptosis is related to many diseases and development. Caspase-9 plays a central role in cell death induced by a variety of apoptosis activators. Cytochrome c, after released from mitochondria, binds to Apaf-1, which forms an apoptosome that in turn binds to and activate procaspase-9. Activated caspase-9 cleaves and activates the effector caspases (caspase-3, -6 and -7), which are responsible for the proteolytic cleavage of many key proteins in apoptosis. The tumor suppressor putative HLA-DR-associated proteins (PHAPs) were recently identified as important regulators of mitochondrion apoptosis. PHAP appears to facilitate apoptosome-medicated caspase-9 activation and to stimulate the mitochondrial apoptotic pathway. PHAP was also shown to oppose both Ras- and Myc-medicated cell transformation.
- 分子量
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Predicted: 29kD
Observed: 29 kD kDa - 基因ID
- 8125
- UniProt
- P39687
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