PPM1D 抗体
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- 抗原 See all PPM1D 抗体
- PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This PPM1D antibody is un-conjugated
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应用范围
- Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human PPM1D:471-570/605
- 亚型
- IgG
- Top Product
- Discover our top product PPM1D Primary Antibody
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anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 201-300) antibody
PPM1D 适用: 人 WB, ELISA, IF (cc), IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 1-250) antibodyPPM1D 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 496-605) antibodyPPM1D 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4D1 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (C-Term) antibodyPPM1D 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) antibodyPPM1D 适用: 人, 小鼠 WB, ELISA, IHC (p), ICC 宿主: 小鼠 Monoclonal 7E11-C5 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 571-602), (C-Term) antibodyPPM1D 适用: 人 WB 宿主: 兔 Polyclonal RB6018 unconjugated
anti-Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D) (AA 183-212) antibodyPPM1D 适用: 人 WB 宿主: 兔 Polyclonal RB33957 unconjugated
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- 应用备注
- IHC-P 1:200-400
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- PPM1D (Protein Phosphatase, Mg2+/Mn2+ Dependent, 1D (PPM1D))
- 别名
- PPM1D (PPM1D 产品)
- 背景
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Synonyms: WPP-DOMAIN INTERACTING PROTEIN 1, EC 3.1.3.16, p53 induced protein phosphatase 1, PP2C delta, PP2CD, protein phosphatase 1D magnesium-dependent delta isoform, Protein phosphatase 2C delta isoform, Protein phosphatase 2C isoform delta, Protein phosphatase magnesium dependent 1 delta, WIP 1, WIP1, AV338790, PPM1D_HUMAN.
Background: PPM1D (Wip) is a serine/threonine phosphatase implicated in cell cycle control, spermatogenesis, and lymphoid cell function. The predicted 605-amino acid PPM1D protein contains 2 putative nuclear localization signals and 3 regions conserved in serine/threonine PP2C phosphatases, as well as characteristics of a type 2C phosphatase, including magnesium dependence and relative insensitivity to okadaic acid. PPM1D expression is induced in response to ionizing radiation in a p53-dependent manner. The accumulation of PPM1D mRNA following ionizing radiation is rapid and transient, and PPM1D protein is localized to the nucleus. PPM1D may contribute to growth inhibitory pathways activated in response to DNA damage in a p53-dependent manner. PPM1D inhibits phosphorylation of the p38 mitogen-activated (MAP)kinase protein. Through p38 MAPK, PPM1D modulates the CDKN2A tumor-suppressor locus. This gene is located in a chromosomal region known to be amplified in breast cancer, (located at 17q22-q23), is amplified in human breast tumor cell lines and in approximately 11 % of primary breast tumors, and appears to lead to cell transformation by abrogating p53 tumor suppressor activity. Inactivation of the p38 MAPK through PPM1D overexpression resulting from PPM1D amplification may contributes to the development of human cancers by suppressing p53 activation. PPM1D null mice have increased susceptibility to pathogens and reduced male fertility and longevity. Function : Required for the relief of p53-dependent checkpoint mediated cell cycle arrest. Binds to and dephosphorylates 'Ser-15' of TP53 and 'Ser-345' of CHEK1 which contributes to the functional inactivation of these proteins. Subunit : Interacts with CHEK1 and CHEK2, dephosphorylates them. Similarity : Belongs to the PP2C family. Contains 1 PP2C-like domain.
- 基因ID
- 8493
- UniProt
- O15297
- 途径
- p53 Pathway, Cell Division Cycle
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