GIPC1 抗体 (AA 171-270)
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- 抗原 See all GIPC1 抗体
- GIPC1 (GIPC PDZ Domain Containing Family, Member 1 (GIPC1))
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抗原表位
- AA 171-270
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适用
- 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This GIPC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB)
- 交叉反应
- 小鼠, 大鼠
- 预测反应
- Human,Cow,Sheep
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human GIPC1?
- 亚型
- IgG
- Top Product
- Discover our top product GIPC1 Primary Antibody
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- 应用备注
- WB 1:300-5000
- 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- GIPC1 (GIPC PDZ Domain Containing Family, Member 1 (GIPC1))
- 别名
- GIPC1 (GIPC1 产品)
- 背景
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Synonyms: C19ORF3, Chromosome 19 open reading frame 3, GIPC, GLUT1 C terminal binding protein, GLUT1CBP, IGF 1 receptor interacting protein 1, IIP 1, IIP1, NIP, PDZ domain-containing protein GIPC1, Regulator of G protein signalling 19 interacting protein 1, RGS19 interacting protein 1, RGS19IP1, SEMCAP, SYNECTIIN, Tax interaction protein 2, TIP 2, GIPC1_HUMAN.
Background: GIPC, for GAIP interacting protein at the C terminus (also designated SEMCAP-1 or synectin), is a PDZ domain containing protein that interacts with RGS-GAIP, a GTPase-activating protein (GAP) for G(a i) subunits. GIPC was also identified as TIP-2, a protein that interacts with the viral oncoprotein TAX, which transactivates viral and cellular promoters through interactions with various transcription factors. PDZ domain-containing proteins are primarily localized to cell-cell junctions in epithelial cells and neurons where they coordinate the assembly of multiprotein complexes. GIPC specifically localizes to clusters of vesicles near the plasma membrane and participates in G protein-coupled signaling pathway involved in regulating clathrin-coated vesicular trafficking. GIPC also associates with membrane bound semaphorin F (M-SemF), which is involved in neuronal axon growth, and it appears to regulate the subcellular distribution of M-SemF in the brain.
- 基因ID
- 10755
- UniProt
- O14908
- 途径
- Dicarboxylic Acid Transport
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