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PSME3 抗体 (AA 181-254)

PSME3 适用: 大鼠 IHC (p) 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6988996
发货至: 中国
  • 抗原 See all PSME3 抗体
    PSME3
    抗原表位
    • 5
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 181-254
    适用
    • 47
    • 21
    • 17
    • 9
    • 7
    • 5
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    大鼠
    宿主
    • 42
    • 7
    克隆类型
    • 44
    • 5
    多克隆
    标记
    • 31
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This PSME3 antibody is un-conjugated
    应用范围
    • 36
    • 18
    • 15
    • 8
    • 6
    • 6
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    大鼠
    预测反应
    Human,Mouse,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human PSME3
    亚型
    IgG
    Top Product
    Discover our top product PSME3 Primary Antibody
  • 应用备注
    IHC-P 1:200-400
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    4 °C,-20 °C
    储存方法
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    有效期
    12 months
  • 抗原
    PSME3
    别名
    PSME3 (PSME3 产品)
    别名
    AA410043 antibody, AU020960 antibody, Ki antibody, PA28gamma antibody, REGgamma antibody, pa28g antibody, Ab2-371 antibody, PA28-gamma antibody, PA28G antibody, REG-GAMMA antibody, psme3b antibody, proteaseome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki) antibody, proteasome activator subunit 3 antibody, proteasome activator subunit 3 S homeolog antibody, Psme3 antibody, PSME3 antibody, psme3.S antibody
    背景

    Synonyms: PA28G, 11S regulator complex gamma subunit, 11S regulator complex subunit gamma, Activator of multicatalytic protease subunit 3, Ki antibody Ki antigen, Ki nuclear autoantigen, Ki, PA28 gamma, PA28 gamma, PA28gamma, Proteasome (prosome, macropain) activator subunit 3 (PA28 gamma, Ki), Proteasome (prosome, macropain) activator subunit 3, Proteasome activator 28 gamma, Proteasome activator 28 subunit gamma, Proteasome activator complex subunit 3, Proteasome activator subunit 3, PSME3, PSME3_HUMAN,

    Background: Subunit of the 11S REG-gamma (also called PA28-gamma) proteasome regulator, a doughnut-shaped homoheptamer which associates with the proteasome. 11S REG-gamma activates the trypsin-like catalytic subunit of the proteasome but inhibits the chymotrypsin-like and postglutamyl-preferring (PGPH) subunits. Facilitates the MDM2-p53/TP53 interaction which promotes ubiquitination- and MDM2-dependent proteasomal degradation of p53/TP53, limiting its accumulation and resulting in inhibited apoptosis after DNA damage. May also be involved in cell cycle regulation. Mediates CCAR2 and CHEK2-dependent SIRT1 inhibition (PubMed:25361978).

    基因ID
    10197
    UniProt
    P61289
    途径
    Mitotic G1-G1/S Phases, DNA Replication, Positive Regulation of Endopeptidase Activity, Hepatitis C, Synthesis of DNA
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