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TRBP 抗体 (AA 21-120) (HRP)

TARBP2P 适用: 小鼠 ELISA, IHC (fro), IHC (p) 宿主: 兔 Polyclonal HRP
产品编号 ABIN6987547
发货至: 中国
  • 抗原 See all TRBP (TARBP2P) 抗体
    TRBP (TARBP2P) (TAR (HIV-1) RNA Binding Protein 2 Pseudogene (TARBP2P))
    抗原表位
    • 14
    • 1
    AA 21-120
    适用
    • 15
    • 2
    • 1
    小鼠
    宿主
    • 16
    克隆类型
    • 16
    多克隆
    标记
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This TRBP antibody is conjugated to HRP
    应用范围
    • 13
    • 13
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    ELISA, Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    交叉反应
    小鼠
    预测反应
    Human,Rat,Cow,Sheep,Pig,Horse
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human TRBP
    亚型
    IgG
    Top Product
    Discover our top product TARBP2P Primary Antibody
  • 应用备注
    IHC-P 1:200-400
    IHC-F 1:100-500
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    TRBP (TARBP2P) (TAR (HIV-1) RNA Binding Protein 2 Pseudogene (TARBP2P))
    别名
    TRBP (TARBP2P 产品)
    别名
    TRBP antibody, TARBP2P1, RISC loading complex RNA binding subunit pseudogene 1 antibody, TARBP2P1 antibody
    背景

    Synonyms: LOQS, Prbp, RISC loading complex subunit TARBP2, RISC-loading complex subunit tarbp2, TAR (HIV 1) RNA binding protein 2, TAR (HIV) RNA binding protein 2, TAR (HIV) RNA-binding protein TRBP1, TAR RNA Binding Protein 2, TAR RNA-binding protein 2, tarbp2, Trans-activation-responsive RNA-binding protein, TRBP, TRBP1, TRBP2, TRBP2_HUMAN.

    Background: Required for formation of the RNA induced silencing complex (RISC). Component of the RISC loading complex (RLC), also known as the micro-RNA (miRNA) loading complex (miRLC), which is composed of DICER1, EIF2C2/AGO2 and TARBP2. Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto EIF2C2/AGO2. EIF2C2/AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. May also play a role in the production of short interfering RNAs (siRNAs) from double-stranded RNA (dsRNA) by DICER1. Binds to the HIV-1 TAR RNA which is located in the long terminal repeat (LTR) of HIV-1, and stimulates translation of TAR-containing RNAs. This is achieved in part at least by binding to and inhibiting EIF2AK2/PKR, thereby reducing phosphorylation and inhibition of EIF2S1/eIF-2-alpha. May also promote translation of TAR-containing RNAs independently of EIF2AK2/PKR.

    基因ID
    6895
    UniProt
    Q15633
    途径
    Regulatory RNA Pathways, Ribonucleoprotein Complex Subunit Organization
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