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DTX3L 抗体 (AA 651-740) (FITC)

DTX3L 适用: 人, 小鼠, 大鼠 FACS, IF (cc), IF (p) 宿主: 兔 Polyclonal FITC
产品编号 ABIN6986786
发货至: 中国
  • 抗原 See all DTX3L 抗体
    DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))
    抗原表位
    • 15
    • 8
    • 7
    • 7
    • 6
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 651-740
    适用
    人, 小鼠, 大鼠
    宿主
    • 42
    • 3
    克隆类型
    • 43
    • 2
    多克隆
    标记
    • 15
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This DTX3L antibody is conjugated to FITC
    应用范围
    • 23
    • 18
    • 13
    • 12
    • 12
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    交叉反应
    人, 小鼠, 大鼠
    预测反应
    Rabbit
    纯化方法
    Purified by Protein A.
    免疫原
    KLH conjugated synthetic peptide derived from human DTX3L
    亚型
    IgG
    Top Product
    Discover our top product DTX3L Primary Antibody
  • 应用备注
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    限制
    仅限研究用
  • 状态
    Liquid
    浓度
    1 μg/μL
    缓冲液
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    有效期
    12 months
  • 抗原
    DTX3L (Deltex E3 ubiquitin ligase 3L (DTX3L))
    别名
    DTX3L (DTX3L 产品)
    别名
    BBAP antibody, RGD1565144 antibody, AU042200 antibody, BC023741 antibody, DTX3L antibody, deltex E3 ubiquitin ligase 3L antibody, deltex 3-like, E3 ubiquitin ligase antibody, probable E3 ubiquitin-protein ligase DTX3 antibody, DTX3L antibody, Dtx3l antibody, LOC100521724 antibody
    背景

    Synonyms: BBAP, E3 ubiquitin-protein ligase DTX3L, B-lymphoma- and BAL-associated protein, Protein deltex-3-like, Rhysin-2, Rhysin2, DTX3L

    Background: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4 (H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation (H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites.

    基因ID
    151636
    UniProt
    Q8TDB6
    途径
    Notch Signaling
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