RUVBL1 抗体 (AA 101-200) (Biotin)
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- 抗原 See all RUVBL1 抗体
- RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))
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抗原表位
- AA 101-200
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适用
- 小鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This RUVBL1 antibody is conjugated to Biotin
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 交叉反应
- 小鼠
- 预测反应
- Human,Rat,Dog,Cow,Sheep,Pig,Horse,Chicken,Rabbit,Zebrafish
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human TIP49A
- 亚型
- IgG
- Top Product
- Discover our top product RUVBL1 Primary Antibody
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IHC-F 1:100-500 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- RUVBL1 (RuvB-Like 1 (E. Coli) (RUVBL1))
- 别名
- TIP49A (RUVBL1 产品)
- 别名
- rvb1 antibody, ecp54 antibody, tip49 antibody, nmp238 antibody, pontin antibody, tip49a antibody, xpontin antibody, pontin52 antibody, TIP49 antibody, wu:fd18e04 antibody, zpontin antibody, ECP54 antibody, INO80H antibody, NMP238 antibody, PONTIN antibody, Pontin52 antibody, RVB1 antibody, TIH1 antibody, TIP49A antibody, Tip49a antibody, 2510009G06Rik antibody, RuvB like AAA ATPase 1 antibody, RuvB-like 1 (E. coli) antibody, RuvB-like 1 antibody, RuvB like AAA ATPase 1 S homeolog antibody, RuvB-like AAA ATPase 1 antibody, RuvB-like protein 1 antibody, RUVBL1 antibody, ruvbl1 antibody, PVX_123295 antibody, Bm1_15605 antibody, ruvb1 antibody, ruvbl1.S antibody, Ruvbl1 antibody
- 背景
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Synonyms: 49 kDa TATA box binding protein interacting protein, 49 kDa TATA box-binding protein-interacting protein, 49 kDa TBP interacting protein, 49 kDa TBP-interacting protein, 54 kDa erythrocyte cytosolic protein, ECP-54, ECP54, ERYTHROCYTE CYTOSOLIC PROTEIN, 54-KD, INO80 complex subunit H, NMP 238, Nuclear matrix protein 238, Pontin 52, PONTIN, RuvB like 1, RuvB-like 1, RUVB1_HUMAN, RUVBL1, RVB1, TAP54 alpha, TAP54-alpha, TIP49, TIP49a, TIP60 associated protein 54 alpha, TIP60-associated protein 54-alpha.
Background: Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (3' to 5') activity. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. RUVBL1 plays an essential role in oncogenic transformation by MYC and also modulates transcriptional activation by the LEF1/TCF1-CTNNB1 complex. May be able to bind plasminogen at cell surface and enhance plasminogen activation.
Essential for cell proliferation. - 基因ID
- 8607
- UniProt
- Q9Y265
- 途径
- Telomere Maintenance
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