DPF3 抗体 (AA 1-100) (AbBy Fluor® 594)
-
- 抗原 See all DPF3 抗体
- DPF3 (D4, Zinc and Double PHD Fingers, Family 3 (DPF3))
-
抗原表位
- AA 1-100
-
适用
- 小鼠
-
宿主
- 兔
-
克隆类型
- 多克隆
-
标记
- This DPF3 antibody is conjugated to AbBy Fluor® 594
-
应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
- 交叉反应
- 小鼠
- 预测反应
- Human,Rat,Cow,Pig,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human CERD4
- 亚型
- IgG
- Top Product
- Discover our top product DPF3 Primary Antibody
-
-
- 应用备注
-
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
-
- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- 有效期
- 12 months
-
- 抗原
- DPF3 (D4, Zinc and Double PHD Fingers, Family 3 (DPF3))
- 别名
- CERD4 (DPF3 产品)
- 别名
- BAF45C antibody, CERD4 antibody, 2810403B03Rik antibody, 6530402L11Rik antibody, C78788 antibody, cer-d4 antibody, si:ch211-268e23.1 antibody, wu:fj43h12 antibody, double PHD fingers 3 antibody, D4, zinc and double PHD fingers, family 3 antibody, DPF3 antibody, Dpf3 antibody, dpf3 antibody
- 背景
-
Synonyms: Zinc finger protein DPF3, DPF3, BRG1-associated factor 45C, BAF45C, Zinc finger protein cer-d4, BAF45C, CERD4
Background: Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity). Muscle-specific component of the BAF complex, a multiprotein complex involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Specifically binds acetylated lysines on histone 3 and 4 (H3K14ac, H3K9ac, H4K5ac, H4K8ac, H4K12ac, H4K16ac). In the complex, it acts as a tissue-specific anchor between histone acetylations and methylations and chromatin remodeling. It thereby probably plays an essential role in heart and skeletal muscle development.
- 基因ID
- 8110
- UniProt
- Q92784
-