TRIM37 (Tripartite Motif Containing 37) is an E3 ubiquitin-protein ligase required to prevent centriole reduplication (PubMed:686, PubMed:972). Probably acts by ubiquitinating positive regulators of centriole reduplication (PubMed:972). Mediates monoubiquitination of Lys-119 of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression: associates with some Polycomb group (PcG) multiprotein PRC2-like complex and mediates repression of target genes (PubMed:042). Has anti-HIV activity (PubMed:724). TRIM37 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human and Mouse samples.
纯化方法
Affinity Purified
免疫原
This antibody was raised against a peptide within the C-terminal region of human TRIM37.
KO Validated
TRIM37
适用: 人
WB
宿主: 兔
Polyclonal
unconjugated
应用备注
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
缓冲液
Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.