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SMC1A 抗体 (C-Term)

SMC1A 适用: 人 WB, IP, ChIP-seq 宿主: 兔 Polyclonal unconjugated
产品编号 ABIN6972754
发货至: 中国
  • 抗原 See all SMC1A 抗体
    SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))
    抗原表位
    • 25
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    C-Term
    适用
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    宿主
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    克隆类型
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    多克隆
    标记
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    This SMC1A antibody is un-conjugated
    应用范围
    • 102
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    Western Blotting (WB), Immunoprecipitation (IP), ChIP DNA-Sequencing (ChIP-seq)
    产品特性
    The Structural Maintenance of Chromosomes (SMC) family proteins play critical roles in various nuclear events that require structural changes of chromosomes, including mitotic chromosome organization, DNA recombination and repair and global transcriptional repression. SMC1 has a myosin-like ATPase domain that serves as a molecular motor to help organize chromatin and is part of the cohesin complex that facilitates chromosome cohesion during the cell cycle. SMC1 and SMC3 form a heterodimeric complex required for metaphase progression in mitotic cells. SMC1 is also involved in DNA damage repair. Subsequent to double strand DNA breaks, SMC1 is phosphorylated by the ATM kinase. Phosphorylated SMC1 is crucial to the successful repair of DNA damage. Defects in SMC1 isoform A are the cause of Cornelia de Lange syndrome type 2, an inherited developmental disorder associated with malformations affecting multiple systems. SMC1-a antibody (pAb) was raised in a Rabbit host. It has been validated for use in ChIP-Seq, Immunoprecipitation and Western blot, it has been shown to react with Human samples.
    纯化方法
    Affinity Purified
    免疫原
    This SMC-α antibody was raised against a peptide within the C-terminal region of human SMC1-α.
    亚型
    IgG
    Top Product
    Discover our top product SMC1A Primary Antibody
  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 缓冲液
    Purified IgG in 70 mM Tris ( pH 8), 105 mM NaCl, 31 mM glycine, 0.07 mM EDTA, 30 % glycerol and 0.035 % sodium azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C
    储存方法
    Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
  • 抗原
    SMC1A (Structural Maintenance of Chromosomes 1A (SMC1A))
    别名
    SMC1-α (SMC1A 产品)
    别名
    CDLS2 antibody, DXS423E antibody, SB1.8 antibody, SMC1 antibody, SMC1L1 antibody, SMC1alpha antibody, SMCB antibody, SMC-1A antibody, NV15570 antibody, 5830426I24Rik antibody, Sb1.8 antibody, Smc1 antibody, Smc1alpha antibody, Smc1l1 antibody, Smcb antibody, mKIAA0178 antibody, smc1 antibody, smc1a antibody, smc1l1 antibody, xSMC1 antibody, smc1aa antibody, structural maintenance of chromosomes 1A antibody, structural maintenance of chromosomes 1A b antibody, structural maintenance of chromosomes 1A L homeolog antibody, SMC1A antibody, smc1a antibody, Smc1a antibody, smc1ab antibody, smc1a.L antibody
    分子量
    160 kDa
    NCBI登录号
    NP_006297
    途径
    Stem Cell Maintenance
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