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PKC beta 抗体 (C-Term)

Name: PKC beta 抗体 (C-Term)
Brand: antibodies-online
SKU: ABIN6972535
Availability: OutOfStock

PRKCB 适用: 人 WB 宿主: 兔 Polyclonal unconjugated

PKC-B antibody (pAb) tested by Western blot. (PKC beta 抗体 (C-Term))

1 image

产品编号 ABIN6972535

发货至: 中国

Datasheet as PDF

抗原 See all PKC beta (PRKCB) 抗体

PKC beta (PRKCB) (Protein Kinase C, beta (PRKCB))
抗原表位
16

16

14

13

11

8

7

7

7

7

6

5

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
C-Term
适用
114

93

89

14

7

6

5

2

2

2

1

1

1

1

1

1
人
宿主
133

4

3

2

1
兔
Compatible Secondaries
克隆类型
132

11
多克隆
标记
57

14

9

7

6

4

4

4

4

4

4

4

2

2

2

2

2

2

2

2

2

2

2
This PKC beta antibody is un-conjugated
应用范围
111

62

46

29

27

26

15

11

7

5

4

2

2

1

1

1
Western Blotting (WB)

产品特性

PKC-B (Protein Kinase C, Beta) ia a calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at Ser-559, Ser-644 and Ser-652. Plays a direct role in the negative feedback regulation of the BCR signaling, by down-modulating BTK function via direct phosphorylation of BTK at Ser-180, which results in the alteration of BTK plasma membrane localization and in turn inhibition of BTK activity. Involved in apoptosis following oxidative damage. Acts as a coactivator of androgen receptor (ANDR)-dependent transcription, by being recruited to ANDR target genes and specifically mediating phosphorylation of Thr-6 of histone H3 (H3T6ph), a specific tag for epigenetic transcriptional activation that prevents demethylation of histone H3 Lys-4 (H3K4me) by LSD1/KDM1A. Under high glucose in pancreatic beta-cells, is probably involved in the inhibition of the insulin gene transcription, via regulation of MYC expression. In endothelial cells, activation of PRKCB induces increased phosphorylation of RB1, increased VEGFA-induced cell proliferation, and inhibits PI3K/AKT-dependent nitric oxide synthase (NOS3/eNOS) regulation by insulin, which causes endothelial dysfunction. Phosphorylates ATF2 which promotes cooperation between ATF2 and JUN, activating transcription. PKC-B antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.

纯化方法

Affinity Purified

免疫原

This antibody was raised against a peptide within the C-terminal region of human PKC-B.

亚型

IgG

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PRKCB 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated

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应用备注

Optimal working dilution should be determined by the investigator.

限制

仅限研究用
缓冲液

Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

-20 °C

储存方法

Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.
抗原

PKC beta (PRKCB) (Protein Kinase C, beta (PRKCB))

别名

PKC-B (PRKCB 产品)

别名

PKC-beta antibody, PKCB antibody, PRKCB1 antibody, PRKCB2 antibody, A130082F03Rik antibody, PKC-Beta antibody, Pkcb antibody, Prkcb1 antibody, Prkcb2 antibody, PKC-B antibody, Prkcb antibody, prkcb1 antibody, zgc:63591 antibody, PKC antibody, PRKCB_tv2 antibody, Pkc53E antibody, prkcb1l antibody, zgc:64063 antibody, protein kinase C beta antibody, protein kinase C, beta antibody, protein kinase C, beta b antibody, protein kinase C, beta a antibody, PRKCB antibody, Prkcb antibody, prkcbb antibody, prkcba antibody

分子量

85 kDa

NCBI登录号

NP_997700

途径

WNT signaling, TCR Signaling, Thyroid Hormone Synthesis, Nuclear Hormone Receptor Binding, Chromatin Binding, Myometrial Relaxation and Contraction, VEGF Signaling, Unfolded Protein Response, BCR Signaling