PHF6 is a member of the plant homeodomain finger (PHF) family, which has a potential rode in regulation of chromatin accessibility to lineage-specific transcription factors as part of the nucleosome remodeling and deacetylase (NuRD) epigenetic complex. PHF6 has been reported as a tumor suppressor in association with hematopoietic malignancies including T-cell acute lymphoblastic leukemia (T-ALL) and acute myeloid leukemia (AML). PHF6 may have tissue-specific expression, and is overexpressed in both breast and colorectal cancers. Germline mutations in PHF6 are the cause of the Börjeson-Forssman-Lehmann X-linked intellectual disability syndrome (BFLS). PHF6 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
纯化方法
Affinity Purified
免疫原
This antibody was generated using a peptide from the N-terminal region of human PHF6 (PHD finger protein 6 isoform 1).
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
缓冲液
Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.