JMJD6 (Jumonji Domain-Containing Protein 6) is a dioxygenase that can both act as a histone arginine demethylase and a lysyl-hydroxylase. JMJD6 acts as an arginine demethylase which demethylates histone H3 at 'Arg-2' (H3R2me) and histone H4 at 'Arg-3' (H4R3me), thereby playing a role in histone code. Required for differentiation of multiple organs during embryogenesis and acts as a key regulator of hematopoietic differentiation. May act as a RNA hydroxylase, as suggested by its ability to bind single strand RNA. JMJD6 antibody (pAb) was raised in a Rabbit host. It has been validated for use in Western blot, it has been shown to react with Human samples.
纯化方法
Affinity Purified
免疫原
This antibody was raised against a peptide within the N-terminal region of human JMJD6.
Optimal working dilution should be determined by the investigator.
限制
仅限研究用
缓冲液
Purified IgG in PBS with 30 % glycerol and 0.035 % sodium azide.
储存液
Sodium azide
注意事项
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
储存条件
-20 °C
储存方法
Avoid repeated freeze/thaw cycles by aliquoting items into single-use fractions for storage at -20°C for up to 2 years. Keep all reagents on ice when not in storage.