Native and recombinant p40 subunit of mouse IL-12 and IL-23. The antibody recognizes p40 monomer, p40 homodimer, IL-12 p70 heterodimer (p40+p35) and IL-23 heterodimer (p40+p19).
纯化方法
Purified from in vitro cultures by protein G affinity chromatography.
Neutralization of mouse IL-12 and IL-23 bioactivity. It is recommended to establish the optimal antibody concentration for the assay system used. The antibody is also suitable for immunoassays.
限制
仅限研究用
浓度
1 mg/mL
缓冲液
supplied at 1 mg/mL in PBS free of preservatives
储存液
Without preservative
储存条件
4 °C,-20 °C
储存方法
Store product at 4-8°C or frozen at -20°C or below. Avoid repeated freezing/ thawing.
有效期
18 months
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Lee, Hoeman, Hardaway, Guloglu, Ellis, Jain, Divekar, Tartar, Haymaker, Zaghouani: "Delayed maturation of an IL-12-producing dendritic cell subset explains the early Th2 bias in neonatal immunity." in: The Journal of experimental medicine, Vol. 205, Issue 10, pp. 2269-80, (2008) (PubMed).
Chackerian, Chen, Brodie, Mattson, McClanahan, Kastelein, Bowman: "Neutralization or absence of the interleukin-23 pathway does not compromise immunity to mycobacterial infection." in: Infection and immunity, Vol. 74, Issue 11, pp. 6092-9, (2006) (PubMed).