Recombinant SARS-CoV-2 Nucleocapsid 抗体 (AA 1-419)
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- 抗原 See all SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N) 抗体
- SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)
- 抗体类型
- Recombinant Antibody
- 片段
- scFv fragment
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抗原表位
- AA 1-419
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适用
- SARS Coronavirus-2 (SARS-CoV-2)
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宿主
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Human
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克隆类型
- Chimeric
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标记
- This SARS-CoV-2 Nucleocapsid antibody is un-conjugated
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应用范围
- ELISA, Colloidal Gold Immunochromatography Assay (GICA)
- 产品特性
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Recombinant anti-SARS-CoV-2 Nucleoprotein Mouse ScFv is expressed from 293 cells (HEK293), It is a chimeric monoclonal antibody combining the mouse variable regions with the constant domains of human IgG1.
Monoclonal mouse (varialbe region)/human (kappa/IgG1 constant)chimeric antibody - 纯化方法
- Affinity-chromatography
- 免疫原
- Recombinant Human Novel Coronavirus Nucleoprotein (N) (1-419aa)
- 克隆位点
- 1A6
- 亚型
- IgG1
- Top Product
- Discover our top product SARS-CoV-2 N Primary Antibody
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- 应用备注
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ELISA 1:10000-1:50000
GICA 1:500-1:2000 - 限制
- 仅限研究用
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- 状态
- Liquid
- 缓冲液
- 50 % Glycerol, 0.01M PBS, pH 7.4, 0.03 % Proclin 300
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Upon receipt, store at -20°C or -80°C. Avoid repeated freeze
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- 抗原
- SARS-CoV-2 Nucleocapsid (SARS-CoV-2 N)
- 别名
- SARS-CoV-2 Nucleocapsid Protein (SARS-CoV-2 N 产品)
- 别名
- nucleocapsid phosphoprotein antibody, N antibody
- 物质类
- Viral Protein
- 背景
- Nucleoprotein packages the positive strand viral genome RNA into a helical ribonucleocapsid (RNP) and plays a fundamental role during virion assembly through its interactions with the viral genome and membrane protein M. It plays an important role in enhancing the efficiency of subgenomic viral RNA transcription as well as viral replication. Coronavirus nucleoproteins are phosphoproteins, and are encoded near the 3' end of the genome. N possesses two RNA-binding domains: an N-terminal domain with adjacent S/R-rich motif and the C-terminal 209 amino acids. N protein is invovled in coronavirus infection with many ways: the C-terminal domain (CTD) of N is important for binding the genomic RNA packaging signal leading to selective genome incorporation, the N3 domain interacts with the endodomain of M to form virions, and the serine-arginine repeat region of N (SR) interacts with the first ubiquitin-like domain of nsp3 in a critical early replication step. Moreover, it has also been demonstrated that N can oligomerize through interactions in the CTD, bind viral RNA through the N-terminal domain, unwind double-stranded nucleic acid in the manner of an RNA chaperone, and pack in a helix through the N-terminal domain, though none of these other functions has yet been demonstrated to be important for infection.
- UniProt
- P0DTC9
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