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Recombinant SARS-CoV-2 Spike S1 抗体 (HRP)

适用: SARS Coronavirus-2 (SARS-CoV-2) ELISA 宿主: Human Monoclonal H6 HRP scFv fragment Recombinant Antibody
产品编号 ABIN6953153
发货至: 中国
  • 抗原 See all SARS-CoV-2 Spike S1 抗体
    SARS-CoV-2 Spike S1
    抗体类型
    Recombinant Antibody
    片段
    scFv fragment
    适用
    • 40
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    SARS Coronavirus-2 (SARS-CoV-2)
    宿主
    • 15
    • 10
    • 5
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    克隆类型
    • 27
    • 9
    • 5
    单克隆
    标记
    • 36
    • 3
    • 1
    • 1
    This SARS-CoV-2 Spike S1 antibody is conjugated to HRP
    应用范围
    • 40
    • 9
    • 8
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA
    产品特性
    Recombinant anti-SARS-CoV-2 spike Mouse ScFv is expressed from 293 cells (HEK293) with a human IgG1 Fc tag on C-terminal.
    Mouse scFv fusion with human IgG1 Fc
    AA 16-685
    纯化方法
    Affinity-chromatography
    免疫原
    Recombinant Human Novel Coronavirus Spike glycoprotein (S) (16-685aa)
    克隆位点
    H6
    亚型
    IgG1
    Featured
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  • 应用备注
    Optimal working dilution should be determined by the investigator.
    限制
    仅限研究用
  • 状态
    Liquid
    缓冲液
    50 % Glycerol, 0.01M PBS, pH 7.4, 0.03 % Proclin 300
    储存液
    ProClin
    注意事项
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    -20 °C,-80 °C
    储存方法
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze
  • 抗原
    SARS-CoV-2 Spike S1
    Abstract
    SARS-CoV-2 Spike S1 产品
    别名
    E2 antibody, Surface Glycoprotein antibody, S antibody
    物质类
    Viral Protein
    背景
    Spike glycoprotein comprises two functional subunits responsible for binding to the host cell receptor (S1 subunit) and fusion of the viral and cellular membranes (S2 subunit). For many coronavirus (CoVs), S is cleaved at the boundary between the S1 and S2 subunits, which remain non-covalently bound in the prefusion conformation. The distal S1 subunit comprises the receptor-binding domain(s) and contributes to stabilization of the prefusion state of the membrane-anchored S2 subunit that contains the fusion machinery. S is further cleaved by host proteases at the so-called S2' site located immediately upstream of the fusion peptide in all CoVs. This cleavage has been proposed to activate the protein for membrane fusion via extensive irreversible conformational changes. However, different CoVs use distinct domains within the S1 subunit to recognize a variety of attachment and entry receptors, depending on the viral species. Endemic human coronaviruses OC43 and HKU1 attach via their S domain A to 5-N-acetyl-9-O-acetyl-sialosides found on glycoproteins and glycolipids at the host cell surface to enable entry into susceptible cells. MERS-CoV S uses domain A to recognize non-acetylated sialoside attachment receptors, which likely promote subsequent binding of domain B to the entry receptor, dipeptidyl-peptidase 4. SARS-CoV and several SARS-related coronaviruses (SARSr-CoV) interact directly with angiotensin-converting enzyme 2 (ACE2) via SB to enter target cells.
    基因ID
    43740568
    UniProt
    P0DTC2
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