HIST1H4A 抗体 (acLys16)
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- 抗原 See all HIST1H4A 抗体
- HIST1H4A (Histone Cluster 1, H4a (HIST1H4A))
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抗原表位
- acLys16
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This HIST1H4A antibody is un-conjugated
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应用范围
- Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- Synthetic peptide corresponding to human histone H4 (acetyl K16).
- 克隆位点
- 2G2
- 亚型
- IgG
- Top Product
- Discover our top product HIST1H4A Primary Antibody
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- 应用备注
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- HIST1H4A (Histone Cluster 1, H4a (HIST1H4A))
- 别名
- HIST1H4A (HIST1H4A 产品)
- 别名
- Hist1h4a antibody, H4FA antibody, histone cluster 1, H3f antibody, histone cluster 1 H4 family member a antibody, histone cluster 1, H4a antibody, Hist1h3f antibody, HIST1H4A antibody, Hist1h4a antibody
- 背景
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Synonyms: Histone H4, HIST1H4A, acetyl-Histone H4 (Lys16), H4K16Ac, histone cluster 4 H4, Histone H4 Acetylated on Lysine 16, H4 histone family
Background: Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Histone H4 are known to be acetylated on Lysine 5, 8, 12, and 16. Acetylations are important for the regulation of histone deposition, transcriptional activation, DNA replication and repair. Hyper-acetylation of the histone tails is shown to neutralize positive charge and weakens histone-DNA and nucleosome-nucleosome interactions that destabilizes chromatin structure and increases the accessibility of DNA to various DNA-binding proteins.
- 基因ID
- 121504
- UniProt
- P62805
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