GLI3 抗体
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- 抗原 See all GLI3 抗体
- GLI3 (GLI Family Zinc Finger 3 (GLI3))
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适用
- 人
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This GLI3 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc))
- 交叉反应
- 人
- 纯化方法
- Purified by Protein A.
- 免疫原
- Recombinant protein within human Gli3 aa 1300-1600.
- 克隆位点
- 45G1
- 亚型
- IgG
- Top Product
- Discover our top product GLI3 Primary Antibody
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- 应用备注
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WB 1:300-5000
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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- 抗原
- GLI3 (GLI Family Zinc Finger 3 (GLI3))
- 别名
- GLI3 (GLI3 产品)
- 别名
- ACLS antibody, GCPS antibody, GLI3-190 antibody, GLI3FL antibody, PAP-A antibody, PAPA antibody, PAPA1 antibody, PAPB antibody, PHS antibody, PPDIV antibody, xgli3 antibody, AI854843 antibody, AU023367 antibody, Bph antibody, Pdn antibody, Xt antibody, add antibody, im:7142603 antibody, GLI3 antibody, GLI family zinc finger 3 antibody, GLI family zinc finger 3 L homeolog antibody, GLI-Kruppel family member GLI3 antibody, GLI3 antibody, Gli3 antibody, gli3.L antibody, gli3 antibody
- 背景
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Synonyms: Transcriptional activator GLI3, GLI3 form of 190 kDa, GLI3 full-length protein, Transcriptional repressor GLI3R, GLI3 C-terminally truncated form, GLI3 form of 83 kDa, GLI3-190, GLI3FL, GLI3-83,
Background: Has a dual function as a transcriptional activator and a repressor of the sonic hedgehog (Shh) pathway, and plays a role in limb development. The full-length GLI3 form (GLI3FL) after phosphorylation and nuclear translocation, acts as an activator (GLI3A) while GLI3R, its C-terminally truncated form, acts as a repressor. A proper balance between the GLI3 activator and the repressor GLI3R, rather than the repressor gradient itself or the activator/repressor ratio gradient, specifies limb digit number and identity. In concert with TRPS1, plays a role in regulating the size of the zone of distal chondrocytes, in restricting the zone of PTHLH expression in distal cells and in activating chondrocyte proliferation. Binds to the minimal GLI-consensus sequence 5'-GGGTGGTC-3'.
- 基因ID
- 2737
- UniProt
- P10071
- 途径
- Hedgehog Signaling
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