DGCR8 抗体
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- 抗原 See all DGCR8 抗体
- DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
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适用
- 人, 小鼠, 大鼠
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This DGCR8 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))
- 交叉反应
- 人, 小鼠, 大鼠
- 纯化方法
- Purified by Protein A.
- 免疫原
- Recombinant human DGCR8 between 400 to C-terminus
- 克隆位点
- 3B11
- 亚型
- IgG
- Top Product
- Discover our top product DGCR8 Primary Antibody
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anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 1-773) antibody
DGCR8 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 1-773) antibodyDGCR8 适用: 人 WB, IP, IF 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 675-771) antibodyDGCR8 适用: 人 WB, ELISA, IHC (p) 宿主: 小鼠 Monoclonal 4G3 unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 675-771) antibodyDGCR8 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 1-773) antibodyDGCR8 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (C-Term) antibodyDGCR8 适用: 人, 小鼠, 大鼠 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 180-229) antibodyDGCR8 适用: 人, 小鼠, 大鼠, Cow, 犬, 豚鼠, 猴, Pig WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (N-Term) antibodyDGCR8 适用: 人, 小鼠, 大鼠, Cow, 犬, 马, 豚鼠, 兔, 斑马鱼 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) (AA 439-466) antibodyDGCR8 适用: 人 WB, ELISA, FACS 宿主: 兔 Polyclonal unconjugated
anti-DiGeorge Syndrome Critical Region Gene 8 (DGCR8) antibodyDGCR8 适用: 人 WB, ELISA 宿主: 兔 Monoclonal 2H2 unconjugated Recombinant Antibody
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- 应用备注
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WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- -20 °C
- 储存方法
- Store at -20°C for 12 months.
- 有效期
- 12 months
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- 抗原
- DGCR8 (DiGeorge Syndrome Critical Region Gene 8 (DGCR8))
- 别名
- DGCR8 (DGCR8 产品)
- 背景
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Synonyms: Microprocessor complex subunit DGCR8, DiGeorge syndrome critical region 8, DGCR8, C22orf12, DGCRK6
Background: Component of the microprocessor complex that acts as a RNA- and heme-binding protein that is involved in the initial step of microRNA (miRNA) biogenesis. Component of the microprocessor complex that is required to process primary miRNA transcripts (pri-miRNAs) to release precursor miRNA (pre-miRNA) in the nucleus. Within the microprocessor complex, DGCR8 function as a molecular anchor necessary for the recognition of pri-miRNA at dsRNA-ssRNA junction and directs DROSHA to cleave 11 bp away form the junction to release hairpin-shaped pre-miRNAs that are subsequently cut by the cytoplasmic DICER to generate mature miRNAs (PubMed:26027739, PubMed:26748718). The heme-bound DGCR8 dimer binds pri-miRNAs as a cooperative trimer (of dimers) and is active in triggering pri-miRNA cleavage, whereas the heme-free DGCR8 monomer binds pri-miRNAs as a dimer and is much less active. Both double-stranded and single-stranded regions of a pri-miRNA are required for its binding (PubMed:15531877, PubMed:15574589, PubMed:15589161, PubMed:16751099, PubMed:16906129, PubMed:16963499, PubMed:17159994). Specifically recognizes and binds N6-methyladenosine (m6A)-containing pri-miRNAs, a modification required for pri-miRNAs processing (PubMed:25799998). Involved in the silencing of embryonic stem cell self-renewal.
- 基因ID
- 4487
- UniProt
- Q8WYQ5
- 途径
- Regulatory RNA Pathways
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