Cullin 4A 抗体
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- 抗原 See all Cullin 4A (CUL4A) 抗体
- Cullin 4A (CUL4A)
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适用
- 人
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This Cullin 4A antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS)
- 交叉反应
- 人
- 纯化方法
- Purified by Protein A.
- 免疫原
- Recombinant protein within human Cullin 4a aa 600-759
- 克隆位点
- 3C3
- 亚型
- IgG
- Top Product
- Discover our top product CUL4A Primary Antibody
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anti-Cullin 4A (CUL4A) (AA 1-759) antibody
CUL4A 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) antibodyCUL4A 适用: 人 WB, IF, IP 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) antibodyCUL4A 适用: 人, 小鼠 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) (AA 1-100) antibodyCUL4A 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) (AA 1-100) antibodyCUL4A 适用: 人 ELISA, IF 宿主: 小鼠 Monoclonal 3H3 unconjugated
anti-Cullin 4A (CUL4A) (AA 1-759) antibodyCUL4A 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) (AA 31-60), (N-Term) antibodyCUL4A 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal RB33954 unconjugated
anti-Cullin 4A (CUL4A) (Middle Region) antibodyCUL4A 适用: 人, 小鼠, 大鼠, 马, 兔, 犬, Cow, 豚鼠 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) antibodyCUL4A 适用: 人, 小鼠, 大鼠 WB, IHC, IF, IC 宿主: 兔 Polyclonal unconjugated
anti-Cullin 4A (CUL4A) (AA 1-61) antibodyCUL4A 适用: 人 ELISA, IF 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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WB 1:300-5000
FCM 1:20-100
IHC-P 1:200-400
IF(IHC-P) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
- 有效期
- 12 months
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- 抗原
- Cullin 4A (CUL4A)
- 别名
- CUL4A (CUL4A 产品)
- 别名
- zgc:64071 antibody, CUL4A antibody, 2810470J21Rik antibody, AW495282 antibody, RGD1563853 antibody, cullin 4A antibody, CUL4A antibody, cul4a antibody, Cul4a antibody
- 背景
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Synonyms: Cullin-4A, CUL-4A, CUL4A,
Background: CUL4A is the ubiquitin ligase component of a multimeric complex involved in the degradation of DNA damage-response proteins. CUL4A is a core component of multiple cullin-RING-based E3 ubiquitin-protein ligase complexes which mediate the ubiquitination of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the E3 ubiquitin-protein ligase complex depends on the variable substrate recognition component. DCX(DET1-COP1) directs ubiquitination of JUN. DCX(DDB2) directs ubiquitination of XPC. DCX(DDB2) ubiquitinates histones H3-H4 and is required for efficient histone deposition during replication-coupled (H3.1) and replication-independent (H3.3) nucleosome assembly, probably by facilitating the transfer of H3 from ASF1A/ASF1B to other chaperones involved in histone deposition. DCX(DTL) plays a role in PCNA-dependent polyubiquitination of CDT1 and MDM2-dependent ubiquitination of TP53 in response to radiation-induced DNA damage and during DNA replication. In association with DDB1 and SKP2 probably is involved in ubiquitination of CDKN1B/p27kip. Is involved in ubiquitination of HOXA9. DCX(DTL) directs autoubiquitination of DTL.
- 基因ID
- 8451
- UniProt
- Q13619
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