Cyclin B2 抗体
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- 抗原 See all Cyclin B2 (CCNB2) 抗体
- Cyclin B2 (CCNB2)
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适用
- 人, 小鼠, 大鼠, 非洲爪蟾
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This Cyclin B2 antibody is un-conjugated
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应用范围
- ELISA, Immunohistochemistry (IHC), Coating (Coat)
- 纯化方法
- Purified by Protein A/G
- 免疫原
- Recombinant full-length Xenopus laevis Cyclin B2 protein
- 克隆位点
- X29-2
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product CCNB2 Primary Antibody
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- 应用备注
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Positive Control: HeLa cells. Human cervical tissue (IHC).
Known Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 有效期
- 24 months
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- 抗原
- Cyclin B2 (CCNB2)
- 别名
- CCNB2 (CCNB2 产品)
- 别名
- HsT17299 antibody, CycB2 antibody, sb:cb303 antibody, cycB2 antibody, LOC100136691 antibody, C-B2 antibody, cyclinb2 antibody, hst17299 antibody, LOC100282653 antibody, cyclin B2 antibody, cyclin B2 S homeolog antibody, CCNB2 antibody, Ccnb2 antibody, ccnb2 antibody, LOC100136691 antibody, LOC100282653 antibody, ccnb2.S antibody
- 背景
- In eukaryotic cells, mitosis is initiated following the activation of a protein kinase known variously as maturation-promoting factor, M phase specific histone kinase or M-phase kinase. This protein kinase is composed of a catalytic subunit (Cdc2), a regulatory subunit (cyclin B) and a low molecular weight subunit (p13-Suc1). The Cdc/cyclin enzyme is subject to multiple levels of control, of which the regulation of the catalytic subunit by tyrosine phosphorylation is the best understood. Tyrosine phosphorylation inhibits the Cdc2/ cyclin B enzyme, and tyrosine dephosphorylation, occurring at the onset of mitosis, directly activates the pre-MPF complex. Evidence has established that B type cyclins not only act on M phase regulatory subunits of the Cdc2 protein kinase, but also activate the Cdc25A and Cdc25B endogenous tyrosine phosphatase, of which Cdc2 is the physiological substrate. The two B type cyclins, cyclin B1 and cyclin B2, have been shown to have distinct tissue distributions.
- 分子量
- 51kDa
- 基因ID
- 9133
- UniProt
- O95067
- 途径
- Cell Division Cycle, M Phase
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