Complement 3d (C3d) (Acute Humoral Rejection Marker) 抗体
适用: 人
Coat, ELISA
宿主: 小鼠
Monoclonal
C3D-2891
unconjugated
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- 抗原
- Complement 3d (C3d) (Acute Humoral Rejection Marker)
- 适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- 非结合性
- 应用范围
- Coating (Coat), ELISA
- 纯化方法
- Purified by Protein A/G
- 免疫原
- Recombinant full-length human Complement C3 protein
- 克隆位点
- C3D-2891
- 亚型
- IgG2b kappa
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-
- 应用备注
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Positive Control: Human kidney or rejected renal transplant tissue.
Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
-
- 浓度
- 200 μg/mL
- 缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 有效期
- 24 months
-
- 抗原
- Complement 3d (C3d) (Acute Humoral Rejection Marker)
- 背景
- The complement component proteins, C2, C3, C4 and C5, are potent anaphylatoxins that are released during complement activation. Binding of these proteins to their respective G protein-coupled receptors, C3aR, C1R and C5aR, induces proinflammatory events, such as cellular degranulation, smooth muscle contraction, arachidonic acid metabolism, cytokine release, leukocyte activation and cellular chemotaxis. C3d is a terminal degradation product of C3 that plays an important role in modulation of the adaptive immune response through the interaction with complement receptor type 2 (CR2). CR2 is important in the switched-isotype, high-affinity and memory humoral immune responses to T-dependent foreign antigens, as well as in the development of the natural antibody repertoire. This pH - and ionic strength-dependent association of C3d with CR2 represents a link between innate and adaptive immunity.
- 分子量
- 35kDa (predicted)
- 基因ID
- 718
- UniProt
- P01024
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