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Thyroglobulin 抗体

TG 适用: 人, 小鼠, 大鼠 IHC, FACS, StM 宿主: 小鼠 Monoclonal 2H11 unconjugated
产品编号 ABIN6940704
发货至: 中国
  • 抗原 See all Thyroglobulin (TG) 抗体
    Thyroglobulin (TG)
    适用
    • 102
    • 35
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    人, 小鼠, 大鼠
    宿主
    • 62
    • 39
    • 4
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    小鼠
    克隆类型
    • 66
    • 41
    单克隆
    标记
    • 67
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    This Thyroglobulin antibody is un-conjugated
    应用范围
    • 42
    • 39
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    Immunohistochemistry (IHC), Flow Cytometry (FACS), Staining Methods (StM)
    特异性
    MAb 2H11 reacts with a partially defined epitope of human thyroglobulin. This epitope is different form the epitope recognized by MAb 6E1. Thyroglobulin is a 660 kDa dimeric pre-protein with mutiple glycosylation sites. It is produced by and processed within the thyroid gland to produce the hormone thyroxine and triiodothyronine. Prior to forming dimers, thyroglobulin monomers undergo conformational maturation in the endoplasmic reticulation. The vast majority of follicular carcinomas of the thyroid will give positive immunoreactivity for anti-thyroglobulin even though sometimes only focally. Poorly differentiated carcinomas of the thyroid are frequently anti-thyroglobulin negative. Adenocarcinomas of other-than-thyroid origin do not react with this antibody. This antibody is useful in identification of thyroid carcinoma of the papillary and follicular types. Presence of thyroglobulin in metastatic lesions establishes the thyroid origin of tumor. Anti-thyroglobulin, combined with anti-calcitonin, can identify medullary carcinomas of the thyroid. Furthermore, anti-thyroglobulin, combined with anti-TTF1, can be a reliable marker to differentiate between primary thyroid and lung neoplasms.
    纯化方法
    Purified by Protein A/G
    免疫原
    Human thyroid follicular cells
    克隆位点
    2H11
    亚型
    IgG1 kappa
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  • 应用备注

    Positive Control: Thyroid.

    Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL, 30 min at RT) (Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    限制
    仅限研究用
  • 浓度
    200 μg/mL
    缓冲液
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-80 °C
    储存方法
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    有效期
    24 months
  • 抗原
    Thyroglobulin (TG)
    别名
    Thyroglobulin (Thyroidal Cell Marker) (TG 产品)
    别名
    TG antibody, cb717 antibody, AITD3 antibody, TGN antibody, Tgn antibody, cog antibody, thyroglobulin antibody, TG antibody, tg antibody, LOC701526 antibody, LOC701756 antibody, LOC100434297 antibody, Tg antibody
    分子量
    660kDa (Dimeric Form)
    基因ID
    7038
    UniProt
    P01266
    途径
    Thyroid Hormone Synthesis
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