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BRCA1 抗体 (AA 445-620)

BRCA1 适用: 人 IHC, ISt, StM 宿主: 小鼠 Monoclonal BRCA1-1398 unconjugated
产品编号 ABIN6940661
发货至: 中国
  • 抗原 See all BRCA1 抗体
    BRCA1 (Breast Cancer 1 (BRCA1))
    抗原表位
    • 21
    • 21
    • 15
    • 15
    • 12
    • 12
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    AA 445-620
    适用
    • 197
    • 34
    • 25
    • 3
    • 2
    • 1
    • 1
    • 1
    宿主
    • 168
    • 34
    • 2
    小鼠
    克隆类型
    • 172
    • 32
    单克隆
    标记
    • 91
    • 17
    • 10
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    This BRCA1 antibody is un-conjugated
    应用范围
    • 124
    • 67
    • 42
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    • 38
    • 37
    • 28
    • 22
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    • 12
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    Immunohistochemistry (IHC), Immunostaining (ISt), Staining Methods (StM)
    纯化方法
    Purified by Protein A/G
    免疫原
    Recombinant human BRCA1 protein fragment (around aa445-620) (exact sequence is proprietary)
    克隆位点
    BRCA1-1398
    亚型
    IgG1 kappa
    Top Product
    Discover our top product BRCA1 Primary Antibody
  • 应用备注

    Positive Control: A431 or HeLa cells. Breast, Ovarian or Renal Cell Carcinoma.

    Known Application: Immunohistochemistry (Formalin-fixed) (2-5 μg/mL for 60 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    限制
    仅限研究用
  • 浓度
    200 μg/mL
    缓冲液
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-80 °C
    储存方法
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    有效期
    24 months
  • 抗原
    BRCA1 (Breast Cancer 1 (BRCA1))
    别名
    BRCA1 (BRCA1 产品)
    别名
    BRCAI antibody, BRCC1 antibody, BROVCA1 antibody, IRIS antibody, PNCA4 antibody, PPP1R53 antibody, PSCP antibody, RNF53 antibody, iris antibody, pscp antibody, brcai antibody, brcc1 antibody, rnf53 antibody, brca1 antibody, BRCA1 antibody, LOC100224649 antibody, BRCA1, DNA repair associated antibody, breast cancer 1 antibody, breast cancer 1, early onset antibody, breast cancer 1 L homeolog antibody, BRCA1 antibody, brca1 antibody, LOC755086 antibody, Brca1 antibody, brca1.L antibody
    背景
    This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability, and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors, DNA damage sensors, and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II, and through the C-terminal domain, also interacts with histone deacetylase complexes. This protein thus plays a role in transcription, DNA repair of double-stranded breaks, and recombination. Mutations in this gene are responsible for approximately 40 % of inherited breast cancers and more than 80 % of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene.
    分子量
    220kDa
    基因ID
    672
    UniProt
    P38398
    途径
    Cell Division Cycle, DNA Damage Repair, Intracellular Steroid Hormone Receptor Signaling Pathway, Positive Regulation of Response to DNA Damage Stimulus
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