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SOX10 抗体 (AA 115-269)

SOX10 适用: 人 WB, FACS, IF, IHC, StM 宿主: 小鼠 Monoclonal SPM607 unconjugated
产品编号 ABIN6940626
发货至: 中国
  • 抗原 See all SOX10 抗体
    SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
    抗原表位
    • 33
    • 16
    • 10
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 115-269
    适用
    • 82
    • 54
    • 39
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    宿主
    • 65
    • 36
    • 2
    小鼠
    克隆类型
    • 55
    • 48
    单克隆
    标记
    • 45
    • 9
    • 6
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SOX10 antibody is un-conjugated
    应用范围
    • 80
    • 36
    • 30
    • 27
    • 24
    • 16
    • 15
    • 14
    • 12
    • 9
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (IHC), Staining Methods (StM)
    特异性
    Recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately to strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
    纯化方法
    Purified by Protein A/G
    免疫原
    Recombinant fragment (aa 115-269) of human SOX10 protein with hexa-histidine tag
    克隆位点
    SPM607
    亚型
    IgG2b kappa
    Top Product
    Discover our top product SOX10 Primary Antibody
  • 应用备注

    Positive Control: HepG2 cells. Melanomas, breast carcinomas, gliomas.

    Known Application: Flow Cytometry (0.5-1 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (0.5-1.0 μg/mL), Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    限制
    仅限研究用
  • 浓度
    200 μg/mL
    缓冲液
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-80 °C
    储存方法
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    有效期
    24 months
  • 抗原
    SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
    别名
    SOX10 (SOX10 产品)
    别名
    DOM antibody, PCWH antibody, WS2E antibody, WS4 antibody, WS4C antibody, SOX-10 antibody, SOX10 antibody, dom antibody, ws4 antibody, Dom antibody, Sox21 antibody, SOX9 antibody, cls/sox10 antibody, zgc:100757 antibody, SRY-box 10 antibody, SRY box 10 antibody, SRY-box 10 L homeolog antibody, SRY (sex determining region Y)-box 10 antibody, SOX10 antibody, Sox10 antibody, sox10.L antibody, sox10 antibody
    分子量
    49-58kDa
    基因ID
    6663
    UniProt
    P56693
    途径
    Chromatin Binding
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