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Chp2 抗体

适用: 人 WB, IF 宿主: 小鼠 Monoclonal CPTC-CHP2-1 unconjugated
产品编号 ABIN6940567
发货至: 中国
  • 抗原 See all Chp2 products
    Chp2
    适用
    • 15
    • 12
    • 12
    • 1
    宿主
    • 14
    • 1
    小鼠
    克隆类型
    • 14
    • 1
    单克隆
    标记
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This Chp2 antibody is un-conjugated
    应用范围
    • 8
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (IF)
    纯化方法
    Purified by Protein A/G
    免疫原
    Recombinant human full-length CHP2 protein
    克隆位点
    CPTC-CHP2-1
    亚型
    IgG2c kappa
  • 应用备注

    Positive Control: MCF-7, PC-3, HT29, K562 or Jurkat cell lysates. Human appendix or testis.

    Known Application: Western Blot (1-2 μg/mL), Immunofluorescence (1-2 μg/mL),Optimal dilution for a specific application should be determined.

    限制
    仅限研究用
  • 浓度
    200 μg/mL
    缓冲液
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-80 °C
    储存方法
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    有效期
    24 months
  • 抗原
    Chp2
    Abstract
    Chp2 产品
    别名
    2010110P09Rik antibody, Cbhp2 antibody, chp-2 antibody, calcineurin-like EF hand protein 2 antibody, calcineurin like EF-hand protein 2 antibody, Chp2 antibody, CHP2 antibody
    背景
    CHP2 (calcineurin B homologous protein 2), also known as hepatocellular carcinoma-associated antigen 520, is a 196 amino acid protein that contains 4 EF-hand domains and plays a potential role in transmembrane Na+/H+ exchange. By binding to and activating NHE-1, CHP2 increases the pH and works to protect cells from serum deprivation-induced death. Though not typically detected in normal tissues, CHP2 is highly expressed in malignantly transformed cells and is therefore considered to be a tumor-associated antigen. Ectopic expression of CHP2 promotes proliferation of HEK293 cells and knockdown of CHP2 mRNA in HepG2 cells inhibits cell proliferation. Like calcineurin B, CHP2 can bind to and stimulate phosphatase activity of calcineurin A and activate the calcineurin/NFAT signaling pathway.
    分子量
    22kDa
    基因ID
    63928
    UniProt
    O43745
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