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ZFYVE28 抗体

ZFYVE28 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal LST2-2426 unconjugated
产品编号 ABIN6940433
发货至: 中国
  • 抗原 See all ZFYVE28 抗体
    ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))
    适用
    • 22
    • 12
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    宿主
    • 20
    • 2
    小鼠
    克隆类型
    • 21
    • 1
    单克隆
    标记
    • 12
    • 2
    • 2
    • 2
    • 2
    • 2
    This ZFYVE28 antibody is un-conjugated
    应用范围
    • 20
    • 13
    • 13
    • 4
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Staining Methods (StM)
    纯化方法
    Purified by Protein A/G
    免疫原
    Recombinant full-length human ZFYVE28 protein
    克隆位点
    LST2-2426
    亚型
    IgG2a kappa
  • 应用备注

    Positive Control: PC3 cells. Testis, Brain, Colon, Kidney or Stomach.

    Known Application: Immunohistochemistry (Formalin-fixed) (0.1-0.2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    限制
    仅限研究用
  • 浓度
    200 μg/mL
    缓冲液
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    储存液
    Sodium azide
    注意事项
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    储存条件
    4 °C,-80 °C
    储存方法
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    有效期
    24 months
  • 抗原
    ZFYVE28 (Zinc Finger, FYVE Domain Containing 28 (ZFYVE28))
    别名
    ZFYVE28 (ZFYVE28 产品)
    别名
    LST2 antibody, LYST2 antibody, 9630058O20Rik antibody, Gm146 antibody, mKIAA1643 antibody, id:ibd1374 antibody, zgc:152894 antibody, zinc finger FYVE-type containing 28 antibody, zinc finger, FYVE domain containing 28 antibody, ZFYVE28 antibody, Zfyve28 antibody, zfyve28 antibody
    背景
    ZFYVE28 belongs to the lst-2 family. It contains 1 FYVE-type zinc finger. The FYVE-type zinc finger mediates the interaction with phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes when not mono-ubiquitinated at Lys-87. Mono-ubiquitination at Lys-87 prevents binding to phosphatidylinositol 3-phosphate (PI3P) and localization to early endosome membranes. ZFYVE28 is a negative regulator of epidermal growth factor receptor (EGFR) signaling. It acts by promoting EGFR degradation in endosomes when not mono-ubiquitinated. The FYVE domain has been identified in a number of unrelated signaling molecules. This protein functions to recruit SMAD2 to the transforming growth factor-beta receptor. The FYVE domain is required to maintain the normal localization of this protein but is not involved in mediating interaction with SMADs.
    分子量
    96kDa
    基因ID
    57732
    途径
    EGFR Signaling Pathway
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