Recombinant PTH 抗体 (AA 1-34)
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- 抗原 See all PTH 抗体
- PTH (Parathyroid Hormone (PTH))
- 抗体类型
- Recombinant Antibody
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抗原表位
- AA 1-34
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PTH antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), Staining Methods (StM)
- 特异性
- Epitope of this MAb maps in the N-terminus of PTH, a hormone produced by the parathyroid gland that regulates the concentration of calcium and phosphorus in extracellular fluid. This hormone elevates blood Ca2+ levels by dissolving the salts in bone and preventing their renal excretion.It is produced in the parathyroid gland as an 84 amino acid single chain polypeptide. It can also be secreted as N-terminal truncated fragments or C-terminal fragments after intracellular degradation, as in case of hypercalcemia. Defects in this gene are a cause of familial isolated hypoparathyroidism (FIH), also called autosomal dominant hypoparathyroidism or autosomal dominant hypocalcemia. FIH is characterized by hypocalcemia and hyperphosphatemia due to inadequate secretion of parathyroid hormone. Symptoms are seizures, tetany and cramps. FIH exist both as autosomal dominant and recessive forms of hypoparathyroidism.
- 交叉反应 (详细)
- Predicted to react with Mouse. Rat. Rabbit. Cow. Dog. Pig. Deer. Orangutan.
- 免疫原
- A synthetic peptide around amino acids 1-34 of human mature-PTH-polypeptide (exact sequence is proprietary)
- 克隆位点
- RPTH-911
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product PTH Primary Antibody
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- 应用备注
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Positive Control: Human parathyroid gland carcinoma.
Known Application: Immunohistochemistry (Formalin-fixed. Not suitable for frozen tissues.) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 有效期
- 24 months
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- 抗原
- PTH (Parathyroid Hormone (PTH))
- 别名
- PTH (PTH 产品)
- 别名
- PTH1 antibody, Pthp antibody, PTH-(1-84) antibody, Pth1 antibody, Pthr1 antibody, PTH antibody, parathyroid hormone antibody, parathyroid hormone S homeolog antibody, PTH antibody, Pth antibody, pth.S antibody
- 物质类
- Hormone
- 分子量
- 9kDa
- 基因ID
- 5741
- UniProt
- P01270
- 途径
- cAMP Metabolic Process, Regulation of Carbohydrate Metabolic Process
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