MAML3 抗体
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- 抗原 See all MAML3 抗体
- MAML3 (Mastermind-Like 3 (MAML3))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MAML3 antibody is un-conjugated
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应用范围
- Immunostaining (ISt), Immunohistochemistry (IHC), Staining Methods (StM)
- 纯化方法
- Purified by Protein A/G
- 免疫原
- Recombinant human MAML3 protein fragment
- 克隆位点
- MAML3-1303
- 亚型
- IgG1 kappa
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anti-Mastermind-Like 3 (MAML3) antibody
MAML3 适用: 人 FACS, IF, IHC (p) 宿主: 小鼠 Monoclonal MAML3-1303 unconjugated
anti-Mastermind-Like 3 (MAML3) (AA 1024-1131) antibodyMAML3 适用: 人 WB, ELISA 宿主: 小鼠 Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) (AA 640-665), (C-Term) antibodyMAML3 适用: 人 FACS, WB, IHC (p) 宿主: 兔 Polyclonal RB18761 unconjugated
anti-Mastermind-Like 3 (MAML3) antibodyMAML3 适用: 人 FACS, WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) (AA 791-840) antibodyMAML3 适用: 人, 小鼠, 兔, 马, 犬, 豚鼠, 猴, 小鸡 WB 宿主: 兔 Polyclonal unconjugated
anti-Mastermind-Like 3 (MAML3) antibodyMAML3 适用: 人 DB 宿主: 小鼠 Monoclonal 797C2a unconjugated
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- 应用备注
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Positive Control: MCF-7 cells. Pancreas or Placenta. Cervix or Colon Carcinoma.
Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1.0 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 有效期
- 24 months
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- 抗原
- MAML3 (Mastermind-Like 3 (MAML3))
- 别名
- MAML3 (MAML3 产品)
- 别名
- AV234550 antibody, BC049812 antibody, Mam-2 antibody, mKIAA1816 antibody, Glrp1 antibody, CAGH3 antibody, ERDA3 antibody, GDN antibody, MAM-2 antibody, MAM2 antibody, TNRC3 antibody, mastermind like 3 (Drosophila) antibody, mastermind-like transcriptional coactivator 3 antibody, mastermind like transcriptional coactivator 3 antibody, Maml3 antibody, MAML3 antibody
- 背景
- MAML3 (mastermind-like protein 3) is a nuclear speckle protein that acts as a transcriptional coactivator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML3 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML3 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4.This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML3 is essential for proper Notch binding, the C-terminal domain of MAML3 is essential for transcriptional activation. Due to its involvement in cell signaling and transcriptional activation, upregulation of MAML3 is thought to be involved in oncogenesis.
- 分子量
- 150-170kDa
- 基因ID
- 55534
- UniProt
- Q96JK9
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