PAPPA 抗体 (AA 351-523)
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- 抗原 See all PAPPA 抗体
- PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))
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抗原表位
- AA 351-523
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PAPPA antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), Staining Methods (StM)
- 特异性
- Pregnancy Associated Plasma Protein (PAPP-A) is found in maternal blood that increases as pregnancy progresses, although it is not specific to pregnancy. It is principally expressed in the syncytiotrophoblast of the placenta, which forms the main source of circulating maternal PAPP-A. It cleaves insulin-like growth factor binding proteins (IGFBPs), IGFBP-4 and IGFBP-5. IGFBP-4 cleavage is enhanced significantly in the presence of bound IGF, whereas IGFBP-5 cleavage is inhibited slightly by IGF presence. It is thought to be involved in local proliferative processes such as wound healing and bone remodeling. Low plasma level of this protein has been suggested as a biochemical marker for pregnancies with aneuploid fetuses. PAPPA has also been suggested as a potential biomarker of acute myocardial infarction and Coronary Artery Disease (CAD).
- 纯化方法
- Purified by Protein A/G
- 免疫原
- Recombinant fragment (within aa 351-523) of human PAPP-A protein (exact sequence is proprietary)
- 克隆位点
- PAPPA-2715
- 亚型
- IgG2b kappa
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anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 1321-1460) antibody
PAPPA 适用: 人, 小鼠 ELISA, IF (cc), IF (p), IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 351-523) antibodyPAPPA 适用: 人 IHC 宿主: 小鼠 Monoclonal MSVA-780M unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 317-532) antibodyPAPPA 适用: 人 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 999-1272) antibodyPAPPA 适用: 小鼠 WB, IP, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 95-302) antibodyPAPPA 适用: 人 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 1270-1558) antibodyPAPPA 适用: 人 WB, IP, IHC, ICC 宿主: 小鼠 Monoclonal H12 unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 85-194) antibodyPAPPA 适用: 人 ELISA, WB 宿主: 小鼠 Monoclonal 1G3 unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 95-388) antibodyPAPPA 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 1270-1558) antibodyPAPPA 适用: 人 WB, IHC, ICC 宿主: 兔 Polyclonal unconjugated
anti-Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA) (AA 1270-1558) antibodyPAPPA 适用: 人 WB, IP, IHC, IF/ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Positive Control: Placenta.
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 有效期
- 24 months
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- 抗原
- PAPPA (Pregnancy-Associated Plasma Protein A, Pappalysin 1 (PAPPA))
- 别名
- PAPPA (PAPPA 产品)
- 别名
- 8430414N03Rik antibody, IGFBP-4ase antibody, PAG1 antibody, PAPP-A antibody, ASBABP2 antibody, DIPLA1 antibody, PAPA antibody, PAPPA1 antibody, Pappa antibody, pappalysin 1 antibody, pregnancy-associated plasma protein A antibody, PAPPA antibody, Pappa antibody, Pappa1 antibody
- 分子量
- 181kDa
- 基因ID
- 5069
- UniProt
- Q13219
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