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- 抗原 See all OGG1 抗体
- OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This OGG1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), Staining Methods (StM)
- 纯化方法
- Purified by Protein A/G
- 免疫原
- Recombinant full-length human OGG1 protein
- 克隆位点
- CPTC-OGG1-1
- 亚型
- IgG2c kappa
- Top Product
- Discover our top product OGG1 Primary Antibody
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anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 1-100), (N-Term) antibody
OGG1 适用: 人, 小鼠, 大鼠, 猴 WB, IHC, ELISA, IP, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 31-345) antibodyOGG1 适用: 人 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 151-250) antibodyOGG1 适用: 人, 小鼠, 大鼠 WB, ELISA, FACS, IHC (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 1-345) antibodyOGG1 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 1-324) antibodyOGG1 适用: 人 WB, IP 宿主: 兔 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 1-324) antibodyOGG1 适用: 人 WB, IF 宿主: 小鼠 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (Internal Region) antibodyVerified OGG1 适用: 人, 大鼠 WB, IHC, ELISA 宿主: 山羊 Polyclonal unconjugated
anti-8-Oxoguanine DNA Glycosylase (OGG1) (AA 31-345) antibodyOGG1 适用: 小鼠 WB, IHC, IP, ICC 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Positive Control: HeLa or Jurkat cells. Kidney, skin or lymph node.
Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 有效期
- 24 months
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- 抗原
- OGG1 (8-Oxoguanine DNA Glycosylase (OGG1))
- 别名
- OGG1 (OGG1 产品)
- 别名
- OGG1 antibody, zgc:158858 antibody, 8-oxoguanine-DNA glycosylase 1 antibody, ARABIDOPSIS 8-OXOGUANINE-DNA GLYCOSYLASE 1 antibody, ATOGG1 antibody, F8K7.14 antibody, F8K7_14 antibody, 19.m02329 antibody, DDBDRAFT_0184479 antibody, DDBDRAFT_0233024 antibody, DDB_0184479 antibody, DDB_0233024 antibody, ogg1 antibody, Tb04.1H19.930 antibody, HMMH antibody, HOGG1 antibody, MUTM antibody, OGH1 antibody, Mmh antibody, 8-oxoguanine DNA glycosylase antibody, 8-oxoguanine DNA glycosylase L homeolog antibody, 8-oxoguanine-DNA glycosylase 1 antibody, 8-OXOGUANINE DNA GLYCOSYLASE antibody, putative 8-oxoguanine DNA glycosylase antibody, 8-oxoguanine DNA-glycosylase antibody, N-glycosylase/DNA lyase OGG1 antibody, 8-oxoguanine DNA-glycosylase 1 antibody, OGG1 antibody, ogg1.L antibody, ogg1 antibody, ECU08_0770 antibody, CA_C2707 antibody, BBOV_I004290 antibody, Smp_074010.1 antibody, LOC9329243 antibody, Tb927.4.2480 antibody, Ogg1 antibody
- 背景
- 8-oxoguanine (8-oxoG), an oxidized form of guanine, is produced by reactive oxygen species in both DNA and nucleotide pools during normal aging. Accumulation of 8-oxoG increases the occurrence of A:T to C:G or G:C to T:A transversionmutations, because 8-oxoG forms a stable basepair with adenine as well as with cytosine. OGG1 (for 8-oxoG DNA glycosylase), also designated MMH, is a DNA repair enzyme that corrects these mutations. Inactivation of the OGG1 gene leads to a mutator phenotype, characterized by the increase in G:C to T:A transversions. The OGG1 gene encodes eight isoforms (OGG1A-C, OGG2A-E) which result from alternative splicing of a single messenger RNA. The OGG1A splice variant is the most prevalent form and localizes to the nucleus, whereas the OGG2A splice variant is targeted to the mitochondria. Guanine is the main target for reactive oxygen species in DNA, and 8-oxoguanine is the most frequent base lesion. Therefore, formation of 8-oxoguanine is an important biomarker of oxidative damage to DNA. It is primarily repaired by the DNA glycosylase OGG1. Furthermore, defects in OGG1 may be a cause of renal cell carcinoma.
- 分子量
- 39kDa
- 基因ID
- 4968
- UniProt
- O15527
- 途径
- DNA Damage Repair
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