LSP1 抗体 (AA 174-278)
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- 抗原 See all LSP1 抗体
- LSP1 (Lymphocyte-Specific Protein 1 (LSP1))
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抗原表位
- AA 174-278
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This LSP1 antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Staining Methods (StM)
- 纯化方法
- Purified by Protein A/G
- 免疫原
- Recombinant fragment of human LSP1 protein (around aa174-278) (exact sequence is proprietary)
- 克隆位点
- LSP1-3025
- 亚型
- IgG1 kappa
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- 应用备注
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Positive Control: Human tonsil, colon, spleen or Hodgkin's lymphoma (IHC-P).
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 有效期
- 24 months
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- 抗原
- LSP1 (Lymphocyte-Specific Protein 1 (LSP1))
- 别名
- LSP1 (LSP1 产品)
- 别名
- LSP1 antibody, Lsp-1 antibody, WP34 antibody, p50 antibody, pp52 antibody, lymphocyte-specific protein 1 antibody, lymphocyte-specific protein 1 L homeolog antibody, lymphocyte specific 1 antibody, LSP1 antibody, lsp1.L antibody, Lsp1 antibody
- 背景
- LSP1 is a hematopoietic-expressed gene that encodes an F-actin-binding, leukocyte-specific (including B and T lymphocytes, granulocytes and macrophages), phosphoprotein. However, mRNA splice variants that do not encode the lympho-specific protein are expressed from this gene in nonlymphoid cell lines as well (myocytes, stromal cells and fibroblasts), suggesting pp52 has a divergent role in signal transduction. The pp52 (LSP1) locus maps to human chromosome 11p15.5, which is implicated in tumor-related chromosomal translocations found in chronic lymphocytic leukemia. The pp52 promoter contains key elements that control transcriptional activity including an initiator specifying the unique 5' terminus of pp52 mRNA, tandem pairs of Ets and SP1 motifs, and a single C/EBP motif. LSP1 binds the cytoskeleton and has been implicated in affecting cytoskeletal remodeling in a variety of leukocyte functions, including cell motility and chemotaxis.
- 分子量
- 52kDa
- 基因ID
- 4046
- UniProt
- P33241
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