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CD11b 抗体 (AA 941-1074)

Name: CD11b 抗体 (AA 941-1074)
Brand: antibodies-online
SKU: ABIN6939813
Availability: OutOfStock

ITGAM 适用: 人 IHC, WB, StM 宿主: 小鼠 Monoclonal ITGAM-3338 unconjugated

Western Blot Analysis of spleen tissue lysate using CD11b Monospecific Mouse Monoclonal Antibody (ITGAM/3338). (CD11b 抗体 (AA 941-1074))

Analysis of Protein Array containing more than 19,000 full-length human proteins using CD11b Monospecific Mouse Monoclonal Antibody (ITGAM/3338). (CD11b 抗体 (AA 941-1074))

PAr

Formalin-fixed, paraffin-embedded human tonsil stained with CD11b Monospecific Mouse Monoclonal Antibody (ITGAM/3338). (CD11b 抗体 (AA 941-1074))

IHC

SDS-PAGE Analysis Purified CD11b Monospecific Mouse Monoclonal Antibody (ITGAM/3338). (CD11b 抗体 (AA 941-1074))

SDS

5 images

产品编号 ABIN6939813

发货至: 中国

Datasheet as PDF

抗原 See all CD11b (ITGAM) 抗体

CD11b (ITGAM) (Integrin alpha M (ITGAM))
抗原表位
16

14

10

7

6

5

5

5

4

3

3

3

3

3

3

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 941-1074
适用
256

163

64

34

20

19

17

14

11

10

7

4

4

2

2

1
人
宿主
140

104

103

2

1

1
小鼠
Compatible Secondaries
克隆类型
252

96

1
单克隆
标记
114

39

30

27

21

10

7

7

5

5

5

5

4

4

4

3

3

3

3

3

3

3

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1
This CD11b antibody is un-conjugated
应用范围
264

83

78

76

56

44

36

22

21

19

13

13

7

6

5

4

4

3

2

2

2

1

1
Immunohistochemistry (IHC), Western Blotting (WB), Staining Methods (StM)

纯化方法

Purified by Protein A/G

免疫原

Recombinant fragment (around aa941-1074) of human ITGAM protein (exact sequence is proprietary)

克隆位点

ITGAM-3338

亚型

IgG1 kappa

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anti-Integrin alpha M (ITGAM) (AA 941-1074) antibody
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anti-Integrin alpha M (ITGAM) (AA 623-728) antibody
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应用备注

Positive Control: Monocytes & granulocytes. Lymph nodes, spleen and tonsil (IHC).
Known Application: Western Blot (0.5-1.0 μg/mL),Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

限制

仅限研究用
浓度

200 μg/mL

缓冲液

10 mM PBS with 0.05 % BSA & 0.05 % azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-80 °C

储存方法

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

有效期

24 months
抗原

CD11b (ITGAM) (Integrin alpha M (ITGAM))

别名

ITGAM (ITGAM 产品)

别名

CD11b/CD18 antibody, CR3 antibody, CR3A antibody, Cd11b antibody, F730045J24Rik antibody, Ly-40 antibody, MAC1 antibody, Mac-1 antibody, Mac-1a antibody, CD11B antibody, MAC-1 antibody, MAC1A antibody, MO1A antibody, SLEB6 antibody, C3bi antibody, integrin subunit alpha M antibody, integrin alpha M antibody, integrin, alpha M (complement component 3 receptor 3 subunit) antibody, integrin alpha-M antibody, ITGAM antibody, Itgam antibody, LOC100351865 antibody

背景

CD11b is a cell adhesion molecule that acts as a receptor for cell surface ligands such as intracellular adhesion molecules (ICAMs) or soluble ligands. Integrins are heterodimeric proteins that contain an a chain and b chain. Integrin aM combines with the Integrin '2 to form a leukocyte-specific integrin referred to as macrophage receptor 1 (Mac-1), or inactivated-C3b (iC3b) receptor 3 (CR3). Integrin aM/'2 is important in the adherence of neutrophils and monocytes to stimulated endothelium, and also in the phagocytosis of complement coated particles. The protein CD11b has been implicated in the various adhesion-related interactions of cells such as monocytes, macrophages, natural killer (NK) cells, and granulocytes. It is part of a heterodimer that consists of CD11b andCD18. It also modulates the uptake of complement-coated particles within the cell. It is commonly used as a microglial marker in tissues derived from the nervous system.

分子量

95kDa & 170kDa

基因ID

3684

UniProt

P11215

途径

Apoptosis, Activation of Innate immune Response, Toll-Like Receptors Cascades, Activated T Cell Proliferation