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Recombinant Insulin Receptor 抗体 (Extracellular Domain)

Name: Recombinant Insulin Receptor 抗体 (Extracellular Domain)
Brand: antibodies-online
SKU: ABIN6939800
Availability: OutOfStock

INSR 适用: 人 IHC, StM 宿主: 兔 Monoclonal INSR-2277R unconjugated Recombinant Antibody

Formalin-fixed, paraffin-embedded human Placenta stained with Insulin Receptor Rabbit Recombinant Monoclonal Antibody (INSR/2277R). (Recombinant Insulin Receptor 抗体 (Extracellular Domain))

IHC

SDS-PAGE Analysis of Purified Insulin Receptor Rabbit Recombinant Monoclonal Antibody (INSR/2277R). (Recombinant Insulin Receptor 抗体 (Extracellular Domain))

SDS

2 images

产品编号 ABIN6939800

发货至: 中国

Datasheet as PDF

抗原 See all Insulin Receptor (INSR) 抗体

Insulin Receptor (INSR)

抗体类型

Recombinant Antibody
抗原表位
16

14

14

12

8

8

8

7

6

6

5

5

5

4

4

4

4

4

4

3

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Extracellular Domain
适用
169

98

82

17

12

9

8

7

6

6

4

3

2

2

1

1

1

1

1

1

1

1
人
宿主
166

22

2

1
兔
Compatible Secondaries
克隆类型
159

32
单克隆
标记
116

16

16

7

6

5

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1
This Insulin Receptor antibody is un-conjugated
应用范围
142

83

53

29

16

15

14

14

13

13

7

5

4

4

3

2

1

1

1
Immunohistochemistry (IHC), Staining Methods (StM)

纯化方法

Purified by Protein A/G

免疫原

Recombinant fragment of extracellular domain of human Insulin Receptor alpha (exact sequence is proprietary)

克隆位点

INSR-2277R

亚型

IgG

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应用备注

Positive Control: Jurkat cells. Human pancreas.
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

限制

仅限研究用
浓度

200 μg/mL

缓冲液

10 mM PBS with 0.05 % BSA & 0.05 % azide.

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C,-80 °C

储存方法

Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

有效期

24 months
抗原

Insulin Receptor (INSR)

别名

INSR (INSR 产品)

别名

CD220 antibody, HHF5 antibody, 4932439J01Rik antibody, D630014A15Rik antibody, IR antibody, IR-A antibody, IR-B antibody, 18402 antibody, CG18402 antibody, DIHR antibody, DILR antibody, DIR antibody, DIRH antibody, DIRbeta antibody, DInR antibody, DInr antibody, Dir-a antibody, Dir-b antibody, Dmel\\CG18402 antibody, INR antibody, INS antibody, Inr antibody, Inr-alpha antibody, Inr-beta antibody, InsR antibody, dINR antibody, dIR antibody, dIRH antibody, dInR antibody, dInr antibody, dInsR antibody, dinr antibody, dir antibody, er10 antibody, inr antibody, insulin/insulin-like growth factor receptor antibody, l(3)05545 antibody, l(3)93Dj antibody, l(3)er10 antibody, lnR antibody, ir-A antibody, CTK-1 antibody, ir antibody, INSR antibody, NV14476 antibody, cd220 antibody, hhf5 antibody, insulin receptor antibody, Insulin-like receptor antibody, insulin receptor L homeolog antibody, INSR antibody, Insr antibody, InR antibody, LOC100122567 antibody, LOC100451802 antibody, insr.L antibody

背景

The insulin receptor (INSR) is a heterodimeric protein complex that has an intracellular subunit, which is disulfide-linked to a transmembrane segment. The insulin ligand binds to the INSR and initiates molecular signaling pathways that promote glucose uptake in cells and glycogen synthesis. Insulin binding to INSR induces phosphorylation of intra-cellular tyrosine kinase domains and recruitment of multiple SH2 and SH3 domain-containing intracellular proteins that serve as signaling intermediates for pleiotropic effects of insulin. Type 1 diabetes is an autoimmune condition of the endocrine pancreas that results in destruction of insulin secreting cells and a progressive loss in insulin-sensitive glucose uptake by cells.

分子量

135kDa

基因ID

3643

UniProt

P06213

途径

NF-kappaB Signaling, RTK signaling, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity