Recombinant Filaggrin 抗体 (AA 198-288)
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- 抗原 See all Filaggrin (FLG) 抗体
- Filaggrin (FLG)
- 抗体类型
- Recombinant Antibody
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抗原表位
- AA 198-288
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适用
- 人
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宿主
- 兔
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克隆类型
- 单克隆
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标记
- This Filaggrin antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), Immunostaining (ISt), Staining Methods (StM)
- 纯化方法
- Purified by Protein A/G
- 免疫原
- Recombinant human Filaggrin protein fragment (around aa 198-288) (exact sequence is proprietary)
- 克隆位点
- FLG-1957R
- 亚型
- IgG
- Top Product
- Discover our top product FLG Primary Antibody
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- 应用备注
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Positive Control: U-251-MG cells. Skin.
Known Application: Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 有效期
- 24 months
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- 抗原
- Filaggrin (FLG)
- 别名
- FLG (FLG 产品)
- 别名
- AW107830 antibody, ft antibody, FLG antibody, ATOD2 antibody, Pflg antibody, Flg antibody, filaggrin antibody, Flg antibody, FLG antibody, LOC100351762 antibody, LOC100728006 antibody
- 背景
- Filaggrin is an intermediate filament-associated protein that aggregates keratin intermediate filaments in mammalian epidermis. It is initially synthesized as a polyprotein precursor, profilaggrin (consisting of multiple filaggrin units of 324 aa each), which is localized in keratohyalin granules, and is subsequently proteolytically processed into individual functional filaggrin molecules.Active filaggrin is present at a level of the epidermis where keratinocytes are in transition between the live nucleated granular layer and the anucleate cornified layer, suggesting that filaggrin aids in the terminal differentiation process by facilitating apoptotic machinery.
- 分子量
- 26-45kDa (Processed), 350kDa (Profilaggrin)
- 基因ID
- 2312
- UniProt
- P20930
- 途径
- Sensory Perception of Sound, Stem Cell Maintenance
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