FcRn 抗体 (AA 24-215)
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- 抗原 See all FcRn 抗体
- FcRn (IgG receptor FcRn (FcRn))
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抗原表位
- AA 24-215
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This FcRn antibody is un-conjugated
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应用范围
- Immunohistochemistry (IHC), Immunostaining (ISt), Staining Methods (StM)
- 纯化方法
- Purified by Protein A/G
- 免疫原
- Recombinant fragment of human FCGRT protein (around aa 24-215) (Exact sequence is proprietary)
- 克隆位点
- FCGRT-2932
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product FcRn Primary Antibody
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- 应用备注
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Positive Control: THP1 or HepG2 cells. Cerebellum or Testis.
Known Application: Immunohistochemistry (Formalin-fixed) (2-4 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by boiling tissue sections in 10 mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- 10 mM PBS with 0.05 % BSA & 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
- 有效期
- 24 months
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- 抗原
- FcRn (IgG receptor FcRn (FcRn))
- 别名
- FCGRT (FcRn 产品)
- 别名
- FCRN antibody, alpha-chain antibody, FcRn antibody, Fc fragment of IgG receptor and transporter antibody, Fc receptor, IgG, alpha chain transporter antibody, FCGRT antibody, Fcgrt antibody
- 背景
- This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. FCGRT is present in the intestinal epithelium of neonates and mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn to acquire passive immunity. FCGRT is comprised of a heavy chain and -2-Microglobulin. FCGRT localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal degradation.
- 分子量
- 46kDa
- 基因ID
- 2217
- UniProt
- P55899
- 途径
- Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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