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- 抗原 See all CDKN1C 抗体
- CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This CDKN1C antibody is un-conjugated
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应用范围
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- Recognizes a protein of 57 kDa, identified as p57Kip2. It shows no cross-reaction with p27Kip1. p57Kip2 is a potent tight-binding inhibitor of several G1 cyclin complexes, and is a negative regulator of cell proliferation. Anti-p57 has been used as an aide in identification of complete hydatidiform mole (CHM) (no nuclear labeling of cytotrophoblasts and stromal cells) from partial hydatidiform mole (PHM) in which both cytotrophoblasts and stromal cells stain. The histological differentiation of complete mole, partial mole, and hydropic spontaneous abortion is problematic. Most complete hydatidiform moles are diploid, whereas most partial moles are triploid. Ploidy studies will identify partial moles, but will not differentiate complete moles from non-molar gestations. Complete moles carry a high risk of persistent disease and choriocarcinoma, while partial moles have a very low risk. In normal placenta, many cytotrophoblast nuclei and stromal cells are labeled with this antibody. Similar findings apply to PHM and hydropic abortus tissues. Intervillous trophoblastic islands (IVTIs) demonstrate nuclear labeling in all three entities and serve as an internal control.
- 交叉反应 （详细）
- Human, Mouse,
- 纯化方法
- 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.
- 免疫原
- Recombinant human p57Kip2 protein
- 克隆位点
- KP10
- 亚型
- IgG2b
- Top Product
- Discover our top product CDKN1C Primary Antibody
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anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) antibody
CDKN1C 适用: 人 WB, ELISA, FACS, IHC 宿主: 小鼠 Monoclonal 8G5D5 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) antibodyCDKN1C 适用: 人 WB, ELISA, FACS, IHC, ICC 宿主: 小鼠 Monoclonal 1F4A9 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) antibodyCDKN1C 适用: 人 IHC (f) 宿主: 兔 Monoclonal unconjugated Recombinant Antibody
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) (AA 291-343) antibodyCDKN1C 适用: 人, 小鼠, 大鼠 ELISA, FACS, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) (N-Term) antibodyCDKN1C 适用: 人 WB, ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) antibodyCDKN1C 适用: 人 IF, FACS, IHC (f) 宿主: 小鼠 Monoclonal SPM308 unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) (pThr310) antibodyCDKN1C 适用: 人 WB, ELISA, IF, ICC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) (AA 1-100) antibodyCDKN1C 适用: 人 WB 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) (AA 267-316), (pThr310) antibodyCDKN1C 适用: 人, 小鼠 WB, ELISA, IF, IHC 宿主: 兔 Polyclonal unconjugated
anti-Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C) (pThr310) antibodyCDKN1C 适用: 人, 小鼠, 大鼠 ELISA, IHC (p), IF (cc), IF (p), IHC (fro) 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Positive Control: LS174T, Raji, HT29, SK-BR3 cells. Colon or Prostate carcinomas.
Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
- 限制
- 仅限研究用
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- 浓度
- 200 μg/mL
- 缓冲液
- Prepared in 10 mM PBS with 0.05 % BSA and 0.05 % azide.
- 储存液
- Sodium azide
- 注意事项
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- 储存条件
- 4 °C,-80 °C
- 储存方法
- Antibody with azide - store at 2 to 8 °C. Antibody is stable for 24 months. Non-hazardous. Also available WITHOUT BSA & azide at 1.0mg/ml.
- 有效期
- 24 months
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- 抗原
- CDKN1C (Cyclin-Dependent Kinase Inhibitor 1C (p57, Kip2) (CDKN1C))
- 别名
- CDKN1C (CDKN1C 产品)
- 别名
- BWCR antibody, BWS antibody, KIP2 antibody, WBS antibody, p57 antibody, p57Kip2 antibody, cb961 antibody, p27Xic1-a antibody, zgc:86618 antibody, AL024410 antibody, CDKI antibody, Kip2 antibody, p57(kip2) antibody, p57KIP2 antibody, cyclin dependent kinase inhibitor 1C antibody, cyclin-dependent kinase inhibitor 1Ca antibody, cyclin-dependent kinase inhibitor 1C (P57) antibody, cyclin-dependent kinase inhibitor 1C antibody, CDKN1C antibody, cdkn1ca antibody, Cdkn1c antibody
- 背景
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Beckwith Wiedemann syndrome (WBS), BWCR, Cyclin dependent kinase inhibitor 1C (CDKN1C), Cyclin dependent kinase inhibitor p57, KIP2, p57, p57Kip2,p57Kip2 (Mitotic Inhibitor/Suppressor Protein)
Cellular localisation: Nuclear - 分子量
- 57kDa
- 基因ID
- 1028, 106070
- UniProt
- P49918
- 途径
- Cell Division Cycle, Dopaminergic Neurogenesis
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