SREBF2 抗体
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- 抗原 See all SREBF2 抗体
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This SREBF2 antibody is un-conjugated
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应用范围
- ELISA, Coating (Coat)
- 特异性
- The low density lipoprotein (LDL) receptor mediates the endocytic uptake of cholesterol-carrying lipoproteins, thereby controlling cholesterol levels in cells and plasma. Transcription of the LDL receptor gene is controlled by a ten base pair sequence in the 5' flanking region, designated sterol regulatory element 1 (SRE-1). When cellular sterol stores are depleted, the element is activated, the gene is transcribed and the cellular uptake of LDL increases. A set of SREbinding proteins (SREBPs) have been identified, including two basic helixloop-helix-leucine zipper (bHLH-zip) transcription factors, designated SREBP-1 and SREBP-2. SREBP-1 and SREBP-2 have been shown to have the same specificity for SRE-1 in vitro and to activate the transcription of reporter genes containing SRE-1 in the same way.
- 交叉反应 (详细)
- Human.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant full-length human SREBF2 protein
- 克隆位点
- SREBP2-1579
- 亚型
- IgG1 kappa
- Top Product
- Discover our top product SREBF2 Primary Antibody
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- 应用备注
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Known_Application: ELISA (For coating, order antibody without BSA), Optimal dilution for a specific application should be determined.
Positive_Control: Ubiqutious expression in adult and fetal tissues. Hep2 or HeLa cells.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- SREBF2 (Sterol Regulatory Element Binding Transcription Factor 2 (SREBF2))
- 别名
- SREBF2 (SREBF2 产品)
- 别名
- SREBF2 antibody, srebp2 antibody, SREBP2 antibody, zgc:158371 antibody, AI608257 antibody, SREBP-2 antibody, SREBP2gc antibody, bHLHd2 antibody, lop13 antibody, nuc antibody, Srebf2_retired antibody, sterol regulatory element binding transcription factor 2 antibody, sterol regulatory element binding factor 2 antibody, sterol regulatory element binding transcription factor 2 L homeolog antibody, SREBF2 antibody, srebf2 antibody, Srebf2 antibody, srebf2.L antibody
- 背景
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AI608257, bHLHd2, Class D basic helix-loop-helix protein 2, OTTHUMP00000028740, Processed sterol regulatory element-binding protein 2, SRBP2_HUMAN, SREBF 2, Srebf2, SREBF2 protein, SREBP 2, SREBP2, SREBP2gc, sterol regulatory element binding factor 2, Sterol regulatory element binding transcription factor 2,SREBP2
Cellular localisation: Nuclear and Cytoplasmic. - 分子量
- 68/125kDa
- 基因ID
- 6721, 443258
- UniProt
- Q12772
- 途径
- Regulation of Lipid Metabolism by PPARalpha
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