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Recombinant SOX2 抗体 (AA 176-305)

SOX2 适用: 人 WB, ELISA, Coat, IHC (f) 宿主: 兔 Monoclonal SOX2-3169R unconjugated Recombinant Antibody
产品编号 ABIN6938414
发货至: 中国
  • 抗原 See all SOX2 抗体
    SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))
    抗体类型
    Recombinant Antibody
    抗原表位
    • 16
    • 16
    • 16
    • 15
    • 15
    • 15
    • 13
    • 11
    • 10
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    • 9
    • 8
    • 7
    • 4
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    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 176-305
    适用
    • 198
    • 94
    • 68
    • 21
    • 13
    • 10
    • 10
    • 10
    • 8
    • 8
    • 6
    • 6
    • 5
    • 5
    • 2
    • 2
    • 1
    • 1
    宿主
    • 161
    • 41
    • 2
    克隆类型
    • 161
    • 43
    单克隆
    标记
    • 98
    • 16
    • 15
    • 10
    • 10
    • 9
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    This SOX2 antibody is un-conjugated
    应用范围
    • 160
    • 107
    • 46
    • 44
    • 43
    • 40
    • 40
    • 28
    • 25
    • 23
    • 17
    • 14
    • 12
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    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), ELISA, Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    特异性
    SOX2 is required for stem cell maintenance in the central nervous system, and it also regulates gene expression in the stomach. SOX2 is necessary for regulating multiple transcription factors that affect Oct 3/4 expression. An essential function of SOX2 is to stabilize embryonic stem cells in a pluripotent state by maintaining the requisite level of Oct 3/4 expression. Reportedly, SOX2 is associated with aggressive phenotypes of breast, head and neck, gastric, colorectal, bladder, and small cell lung cancers. However, SOX2 is expressed in a high percentage of lung squamous cell carcinomas and has been shown to be an independent favorable prognostic marker.
    交叉反应 (详细)
    Human. Mouse. Dog
    纯化方法
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    免疫原
    Recombinant fragment (within aa176-305) of human SOX2 protein (exact sequence is proprietary)
    克隆位点
    SOX2-3169R
    亚型
    IgG
    Top Product
    Discover our top product SOX2 Primary Antibody
  • 应用备注

    Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 min at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: A549, NCCIT cells. Lung or Cervical carcinoma.

    限制
    仅限研究用
  • 浓度
    1.0 mg/mL
    缓冲液
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    储存液
    Azide free
    储存条件
    -20 °C,-80 °C
    储存方法
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    有效期
    24 months
  • 抗原
    SOX2 (SRY (Sex Determining Region Y)-Box 2 (SOX2))
    别名
    SOX2 (SOX2 产品)
    别名
    ANOP3 antibody, MCOPS3 antibody, RGD1565646 antibody, Sox-2 antibody, lcc antibody, ysb antibody, cb236 antibody, wu:fb83g04 antibody, wu:fc14d07 antibody, zgc:65860 antibody, zgc:77389 antibody, SRY-box2 antibody, Xsox-2 antibody, anop3 antibody, mcops3 antibody, sox-2 antibody, SRY-box 2 antibody, SRY box 2 antibody, SRY (sex determining region Y)-box 2 antibody, SRY-box 2 S homeolog antibody, SOX2 antibody, Sox2 antibody, sox2 antibody, sox2.S antibody
    背景
    ANOP3, Delta EF2a, MCOPS3 (Microphthalmia Syndromic type 3), SOX-2, SRY (sex determining region Y) box 2, SRY related HMG box 2, Transcription factor SOX-2, ysb,SOX2 (Embryonic Stem Cell Marker)
    Cellular localisation: Nuclear
    分子量
    34kDa
    基因ID
    6657, 518438
    UniProt
    P48431
    途径
    Dopaminergic Neurogenesis, Sensory Perception of Sound, Stem Cell Maintenance, Cell RedoxHomeostasis
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