PPP3R1 抗体
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- 抗原 See all PPP3R1 抗体
- PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This PPP3R1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- Calcineurin is an enzyme that dephosphorylates serine and threonine residues in proteins. It is a heterodimer of a 59 kDa catalytic A subunit and a 19 kDa regulatory B subunit that is activated by the binding of calcium ions and calmodulin. Calcineurin is expressed in many tissues, but its levels are highest in the brain, where it may play a role in learning and memory. It has many substrates, including NFAT, a transcription factor that is activated by dephosphorylation. Complexes of the immuno-suppressants cyclosporine and FK506 with immunophilin proteins such as cyclophilin and FKBP12 are potent and specific inhibitors of Calcineurin activity. Alterations in Calcineurin activity are suspected to play a role in cardiac hypertrophy and graft versus host disease in organ transplantation.
- 交叉反应 （详细）
- Human. Xenopus laevis.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant full-length human Calcineurin B protein
- 克隆位点
- BE2-1
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product PPP3R1 Primary Antibody
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anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 1-170) antibody
PPP3R1 适用: 人 WB, ELISA, IF 宿主: 小鼠 Monoclonal 4E1 unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) antibodyPPP3R1 适用: 人, 大鼠, 小鼠 WB, IHC, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 1-170) antibodyPPP3R1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 11-170) antibodyPPP3R1 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) antibodyPPP3R1 适用: 人, 大鼠, 小鼠 ELISA, IHC 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 1-154) antibodyPPP3R1 适用: 人, 大鼠, 小鼠, Cow, 小鸡 WB, IHC, IHC (p) 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (AA 11-170) antibodyPPP3R1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) antibodyPPP3R1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal CALNB-2342 unconjugated
anti-Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1) (N-Term) antibodyPPP3R1 适用: 人, 大鼠, 小鼠, Cow, 兔, 非洲爪蟾, 豚鼠, 斑马鱼, 马, 小鸡, 猴, Bat WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Known_Application: ELISA (For coating, order antibody without BSA), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: HeLa, MCF-7 or A431 cells. Human brain, breast or stomach tissue.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- PPP3R1 (Protein Phosphatase 3, Regulatory Subunit B, alpha (PPP3R1))
- 别名
- PPP3R1 (PPP3R1 产品)
- 背景
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Calcineurin B, type I (19 kDa), Calcineurin subunit B type 1, CALNB1, Cna2, CNB, CNB1, Ppp3r1, protein phosphatase 3 (formerly 2B), regulatory subunit B, 19 kDa, alpha isoform (calcineurin B, type I),Calcineurin B / PPP3R1
Cellular localisation: Cytoplasmic. - 分子量
- 19kDa
- 基因ID
- 5534, 280604
- UniProt
- P63098
- 途径
- RTK signaling, WNT signaling, Fc-epsilon Receptor Signaling Pathway, Protein targeting to Nucleus, VEGF Signaling, BCR Signaling
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