NKX6-1 抗体
-
- 抗原 See all NKX6-1 抗体
- NKX6-1 (NK6 Homeobox 1 (NKX6-1))
-
适用
- 人
-
宿主
- 小鼠
-
克隆类型
- 单克隆
-
标记
- This NKX6-1 antibody is un-conjugated
-
应用范围
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- Members of the Nkx family of homeodomain proteins are key regulators of growth and development in several tissues, including brain, heart and pancreas. During neural development, sonic hedgehog (Shh) is known to control cell fate and mitogenesis, which is correlated with Shh dose-dependent expression of several genes, including Nkx-6.1. Specifically, Nkx-6.1 is responsible for cellular differentiation in the ventral neural tube and spinal meninges in response to Shh. In the pancreas, Nkx-6.1 is exclusively expressed in the islets of Langerhans in differentiating and mature B cells, which produce Insulin. The presence of Pdx-1 is required for the expression of Nkx-6.1 as well as other pancreatic B cell specific genes, including Insulin, Glut2 and IAPP. Subsequently, Nkx-6.1 binds to the DNA consensus sequence, TTAATTAC, to direct the repression of specific genes in B cells. Nkx6.1 is highly expressed in pancreatic and duodenal well-differentiated neuroendocrine tumors (WDNETS) and in metastatic WDNETS, is a highly specific marker of tumors of pancreatic origin. It has thus been suggested that Nkx6.1 is a useful inclusion into IHC panels for identifying primary sites of WDNETS.
- 交叉反应 （详细）
- Human.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant full-length human NKX6.1 protein
- 克隆位点
- NKX61-2561
- 亚型
- IgG2c kappa
- Top Product
- Discover our top product NKX6-1 Primary Antibody
-
anti-NK6 Homeobox 1 (NKX6-1) antibody
NKX6-1 适用: 人 IHC, StM 宿主: 小鼠 Monoclonal NKX61-2561 unconjugated
anti-NK6 Homeobox 1 (NKX6-1) (AA 1-367) antibodyNKX6-1 适用: 人 WB, IHC, ICC, IP 宿主: 兔 Polyclonal unconjugated
anti-NK6 Homeobox 1 (NKX6-1) (AA 191-275) antibodyNKX6-1 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 1B7 unconjugated
anti-NK6 Homeobox 1 (NKX6-1) (Internal Region) antibodyNKX6-1 适用: 人, 小鼠, 大鼠 WB, ELISA, ICC, IF 宿主: 兔 Polyclonal unconjugated
anti-NK6 Homeobox 1 (NKX6-1) antibodyNKX6-1 适用: 人 WB, IHC 宿主: 兔 Polyclonal unconjugated
anti-NK6 Homeobox 1 (NKX6-1) (AA 285-314) antibodyNKX6-1 适用: 人, 小鼠 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-NK6 Homeobox 1 (NKX6-1) (N-Term) antibodyNKX6-1 适用: 人, 小鼠, 大鼠, Pig, 兔, 犬, 马, Cow, 猴, Hamster WB 宿主: 兔 Polyclonal unconjugated
anti-NK6 Homeobox 1 (NKX6-1) (N-Term) antibodyNKX6-1 适用: 人, 小鼠, 大鼠, Pig, 兔, 犬, 马, Cow, 斑马鱼 WB 宿主: 兔 Polyclonal unconjugated
anti-NK6 Homeobox 1 (NKX6-1) (AA 284-312) antibodyNKX6-1 适用: 人 WB, ELISA 宿主: 兔 Polyclonal unconjugated
anti-NK6 Homeobox 1 (NKX6-1) (AA 284-314), (C-Term) antibodyNKX6-1 适用: 人, 小鼠 WB, EIA 宿主: 兔 Polyclonal unconjugated
-
- 应用备注
-
Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Human fetal small intestine lysate or pancreas tissue.
- 限制
- 仅限研究用
-
- 浓度
- 1.0 mg/mL
- 缓冲液
- Purified Ab WITHOUT BSA and Azide at 1.0mg/ml
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
-
- 抗原
- NKX6-1 (NK6 Homeobox 1 (NKX6-1))
- 别名
- NKX6-1 (NKX6-1 产品)
- 别名
- nkx6a antibody, nkx6.1 antibody, NKX6.1 antibody, NKX6A antibody, zgc:92879 antibody, Nkx6.1 antibody, Nkx61 antibody, Nkx6a antibody, NK6 homeobox 1 antibody, NK6 homeobox 1 L homeolog antibody, nkx6-1 antibody, NKX6-1 antibody, nkx6.1 antibody, nkx6-1.L antibody, Nkx6-1 antibody
- 背景
-
Homeobox protein NK-6 homolog A, NK homeobox, family 6, A, NK6 homeobox 1, NK6 transcription factor homolog A, NK6 transcription factor related, locus 1 (Drosophila), NKX6-1, NKX6A,NKX6.1 (Marker for Pancreatic and Duodenal Neuroendocrine Tumors)
Cellular localisation: Nuclear - 分子量
- 40-50kDa
- 基因ID
- 4825, 546270
- UniProt
- P78426
- 途径
- Dopaminergic Neurogenesis, Positive Regulation of Peptide Hormone Secretion
-
