MUC4 抗体 (AA 1730-1864)
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- 抗原 See all MUC4 抗体
- MUC4 (Mucin 4, Cell Surface Associated (MUC4))
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抗原表位
- AA 1730-1864
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MUC4 antibody is un-conjugated
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应用范围
- Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. MUC-4 transcripts have been detected in normal respiratory epithelium and lung. MUC-4 is a very specific (100 % ) and sensitive (90 %) marker of lung adenocarcinomas and is negative for mesotheliomas. Reportedly, MUC-4 expression in invasive ductal carcinoma of the pancreas is an independent factor for poor prognosis.
- 交叉反应 (详细)
- Human.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant fragment (around aa 1730-1864) of human MUC4 protein (exact sequence is proprietary)
- 克隆位点
- MUC4-3105
- 亚型
- IgG2b kappa
- Top Product
- Discover our top product MUC4 Primary Antibody
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- 应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: Stomach, Colon or esophagus.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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- 抗原
- MUC4 (Mucin 4, Cell Surface Associated (MUC4))
- 别名
- MUC4 (MUC4 产品)
- 别名
- 4933405I11Rik antibody, Asgp antibody, ASGP antibody, HSA276359 antibody, MUC-4 antibody, ASGP-1 antibody, Psmc antibody, mucin 4 antibody, mucin 4, cell surface associated antibody, Muc4 antibody, MUC4 antibody
- 背景
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Ascites sialoglycoprotein 1, Ascites sialoglycoprotein 2, Ascites sialoglycoprotein, ASGP, ASGP-1, ASGP-2, Mucin 4 cell surface associated, Mucin-4 beta chain, Pancreatic adenocarcinoma mucin, Testis mucin, Tracheobronchial mucin,MUC4 (Mucin 4 / Gastric Mucin)
Cellular localisation: Cytoplasmic - 分子量
- 235kDa
- 基因ID
- 4585, 369646
- UniProt
- Q99102
- 途径
- Regulation of Leukocyte Mediated Immunity
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