MAML2 抗体
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- 抗原 See all MAML2 抗体
- MAML2 (Mastermind-Like 2 (MAML2))
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适用
- 人
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宿主
- 小鼠
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克隆类型
- 单克隆
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标记
- This MAML2 antibody is un-conjugated
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应用范围
- Western Blotting (WB), Immunofluorescence (IF), Flow Cytometry (FACS), Immunostaining (ISt), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- 特异性
- MAML2 (mastermind-like protein 2), also known as MAM2, MAM3 or MLLMAML2, is a nuclear speckle protein that acts as a transcriptional co-activator for Notch receptors. The Notch signaling pathway influences cell fate by regulating the ability of precursor cells to properly respond to developmental signals. MAML2 is a member of the mastermind-like family of proteins that are human homologs of the Drosophila melanogaster mastermind protein. Through its N-terminal region, MAML2 interacts with the ankyrin repeats of the Notch proteins Notch 1, Notch 2, Notch 3 and Notch 4. This interaction leads to formation of a DNA-binding complex with the Notch proteins and RBP-J a complex that can then induce HES1 gene expression. While the N-terminal domain of MAML2 is essential for proper Notch binding, the C-terminal domain of MAML2 is essential for transcriptional activation. A chromosomal aberration involving the gene encoding MAML2 is implicated in mucoepidermoid carcinomas, clear cell hidradenomas and benign Warthin tumors.
- 交叉反应 （详细）
- Human.
- 纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- 免疫原
- Recombinant human MAML2 fragment
- 克隆位点
- MAML2-1302
- 亚型
- IgG2a kappa
- Top Product
- Discover our top product MAML2 Primary Antibody
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anti-Mastermind-Like 2 (MAML2) antibody
MAML2 适用: 人 WB, IF, IHC, FACS, ISt, StM 宿主: 小鼠 Monoclonal MAML2-1302 unconjugated
anti-Mastermind-Like 2 (MAML2) (AA 347-506) antibodyMAML2 适用: 人 WB, IHC, ELISA 宿主: 兔 Polyclonal unconjugated
anti-Mastermind-Like 2 (MAML2) (AA 796-894) antibodyMAML2 适用: 人 WB, ELISA 宿主: 小鼠 Monoclonal 4A1 unconjugated
anti-Mastermind-Like 2 (MAML2) (AA 780-814) antibodyMAML2 适用: 人 WB, IHC (p) 宿主: 兔 Polyclonal RB52651 unconjugated
anti-Mastermind-Like 2 (MAML2) (AA 750-850) antibodyMAML2 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated
anti-Mastermind-Like 2 (MAML2) (AA 169-218) antibodyMAML2 适用: 小鼠 WB 宿主: 兔 Polyclonal unconjugated
anti-Mastermind-Like 2 (MAML2) (AA 324-373) antibodyMAML2 适用: 人, 小鼠 WB 宿主: 兔 Polyclonal unconjugated
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- 应用备注
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Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Positive_Control: MCF-7 cells. Pancreas or Placenta. Bladder or Colon Carcinoma.
- 限制
- 仅限研究用
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- 浓度
- 1.0 mg/mL
- 缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- 储存液
- Azide free
- 储存条件
- -20 °C,-80 °C
- 储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- 有效期
- 24 months
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