Recombinant IGHG4 抗体
Quick Overview for Recombinant IGHG4 抗体 (ABIN6937505)
抗原
抗体类型
适用
宿主
克隆类型
标记
应用范围
克隆位点
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特异性
- The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells.IgG4 is overexpressed in inflammatory pseudotumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.
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交叉反应 （详细）
- Human.
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纯化方法
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
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免疫原
- Recombinant human IGHG4 fragment
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亚型
- IgG1 kappa
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anti-Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4) antibody
IGHG4 适用: 人 IHC, ISt, StM 宿主: 兔 Monoclonal IGHG4-2042R unconjugated Recombinant Antibody
anti-Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4) (AA 1-473) antibodyIGHG4 适用: 人 WB 宿主: 小鼠 Polyclonal unconjugated
anti-Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4) antibodyIGHG4 适用: 人 IHC, ISt, StM 宿主: 小鼠 Monoclonal rIGHG4-1345 unconjugated Recombinant Antibody
anti-Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4) antibodyIGHG4 适用: 人 IHC, ISt, StM 宿主: 小鼠 Monoclonal IGHG4-1345 unconjugated
anti-Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4) (AA 78-105) antibodyIGHG4 适用: 人 WB 宿主: 兔 Polyclonal RB33089 unconjugated
anti-Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4) (Middle Region) antibodyIGHG4 适用: 人 WB, EIA 宿主: 兔 Polyclonal unconjugated
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应用备注
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Known_Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues is enhanced by heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0 for 45 min at 95°C followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.
Positive_Control: Tonsil.
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限制
- 仅限研究用
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浓度
- 1.0 mg/mL
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缓冲液
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
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储存液
- Azide free
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储存条件
- -20 °C,-80 °C
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储存方法
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
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有效期
- 24 months
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- IGHG4 (Immunoglobulin Heavy Constant gamma 4 (G4m Marker) (IGHG4))
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别名
- IGHG4
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背景
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Ig gamma 4 chain C region, IGHG4, Immunoglobulin heavy constant gamma 4 (G4m marker),IgG4 (Ig Heavy Constant Gamma 4) (G4m Marker)
Cellular localisation: Cytoplasmic -
分子量
- 150kDa
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基因ID
- 3503, 510635
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UniProt
- P01861
抗原
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