我们推荐在您的浏览器上开启Javascript，以获得最佳效果。

SNCA 抗体 (pSer129) (HRP)

Name: SNCA 抗体 (pSer129) (HRP)
Brand: antibodies-online
SKU: ABIN6932879
Availability: OutOfStock

SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 HRP

Western Blot analysis of Human Alpha Synuclein showing detection of Alpha Synuclein pSer129 protein using Rabbit Anti-Alpha Synuclein pSer129 Monoclonal Antibody, Clone J18 (ABIN6932879). (SNCA 抗体 (pSer129) (HRP))

Immunohistochemistry analysis using Mouse Anti-Alpha Synuclein pSer129 Monoclonal Antibody, Clone J18 (ABIN6932879). (SNCA 抗体 (pSer129) (HRP))

IHC

C57/BL6 mice were injected with sonicated recombinant mouse alpha synuclein monomers or fibrils at 8 weeks of age. (SNCA 抗体 (pSer129) (HRP))

IHC

Dot Blot analysis using Rabbit Anti-Alpha Synuclein pSer129 Monoclonal Antibody, Clone J18 (ABIN6932879). (SNCA 抗体 (pSer129) (HRP))

Western Blot analysis of Mouse Brain showing detection of Alpha Synuclein pSer129 protein using Rabbit Anti-Alpha Synuclein pSer129 Monoclonal Antibody, Clone J18 (ABIN6932879). (SNCA 抗体 (pSer129) (HRP))

5 images

产品编号 ABIN6932879

发货至: 中国

Datasheet as PDF

抗原 See all SNCA 抗体

SNCA (Synuclein, alpha (SNCA))
抗原表位
68

28

28

17

16

15

14

11

9

5

4

4

4

4

4

3

3

3

3

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
AA 124-134, pSer129
适用
292

189

188

14

10

10

9

7

7

5

2

2

1

1

1
人
宿主
227

103

5

3

1

1
兔
Compatible Secondaries
克隆类型
217

124
单克隆
标记
145

24

22

15

11

8

8

7

7

7

5

5

5

5

5

5

5

5

5

5

5

5

5

5

5

5

5

2
This SNCA antibody is conjugated to HRP
应用范围
223

164

109

72

68

65

56

52

48

41

23

18

10

8

7

2

2

2

1

1

1
Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunocytochemistry (ICC)

特异性

Expressed principally in brain but is also expressed in low concentrations in all tissues examined except in liver. Concentrated in presynaptic nerve terminals.,Binds to phosphorylated serine 129 on alpha synuclein. Does not detect unphosphorylated serine 129 alpha synuclein

交叉反应

人, 小鼠

纯化方法

Affinity Purified

免疫原

Human alpha synuclein AA 124-134: AYEMP-pS-EEGYQ-Cys

克隆位点

J18

亚型

IgG

Top Product

Discover our top product SNCA Primary Antibody
anti-Synuclein, alpha (SNCA) (pSer129) antibody
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Synuclein, alpha (SNCA) (AA 40-140), (pSer129) antibody (Atto 488)
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 488

anti-Synuclein, alpha (SNCA) (AA 40-140), (pSer129) antibody (Atto 390)
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal Atto 390

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody
SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 unconjugated

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (FITC)
SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 FITC

anti-Synuclein, alpha (SNCA) (AA 124-134), (pSer129) antibody (PE)
SNCA 适用: 人 WB, ELISA, IHC, ICC 宿主: 兔 Monoclonal J18 PE

anti-Synuclein, alpha (SNCA) (AA 61-140) antibody
SNCA 适用: 人 WB, IF 宿主: 兔 Polyclonal unconjugated

anti-Synuclein, alpha (SNCA) (AA 40-140), (pSer129) antibody
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal unconjugated

anti-Synuclein, alpha (SNCA) (AA 40-140), (pSer129) antibody (HRP)
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal HRP

anti-Synuclein, alpha (SNCA) (AA 40-140), (pSer129) antibody (FITC)
SNCA 适用: 人, 大鼠, 小鼠 WB, ELISA, IHC, IF, ICC 宿主: 兔 Polyclonal FITC

应用备注
- WB (1:500)
- optimal dilutions for assays should be determined by the user.
说明

A 1:500 dilution of ABIN6932879 was sufficient for detection of Alpha Synuclein pSer129 in 10 μg of Mouse Brain by ECL immunoblot analysis using Goat Anti-Rabbit IgG:HRP as the secondary antibody.

限制

仅限研究用
状态

Liquid

浓度

1 mg/mL

缓冲液

PBS pH 7.4, 50 % glycerol, 0.09 % Sodium azide, Storage buffer may change when conjugated

储存液

Sodium azide

注意事项

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

储存条件

4 °C

储存方法

Conjugated antibodies should be stored at 4°C
抗原

SNCA (Synuclein, alpha (SNCA))

别名

Alpha Synuclein (SNCA 产品)

别名

snca antibody, MGC64356 antibody, LOC619283 antibody, NACP antibody, alphaSYN antibody, PARK1 antibody, PARK4 antibody, PD1 antibody, synuclein alpha L homeolog antibody, alpha-synuclein antibody, synuclein alpha antibody, synuclein, alpha antibody, snca.L antibody, LOC619283 antibody, SNCA antibody, Snca antibody

背景

Alpha-Synuclein (SNCA) is expressed predominantly in the brain, where it is concentrated in presynaptic nerve terminals (1). Alpha-synuclein is highly expressed in the mitochondria of the olfactory bulb, hippocampus, striatum and thalamus (2). Functionally, it has been shown to significantly interact with tubulin (3), and may serve as a potential microtubule-associated protein. It has also been found to be essential for normal development of the cognitive functions, inactivation may lead to impaired spatial learning and working memory (4). SNCA fibrillar aggregates represent the major non A-beta component of Alzheimers disease amyloid plaque, and a major component of Lewy body inclusions, and Parkinson's disease. Parkinson's disease (PD) is a common neurodegenerative disorder characterized by the progressive accumulation in selected neurons of protein inclusions containing alpha-synuclein and ubiquitin (5, 6). Alpha synuclein phosphorylated at serine 129 constitutes 90 % of the alpha synuclein found in Lewy bodies (7, 8).

基因ID

6622

NCBI登录号

NP_000336

UniProt

P37840

途径

Synaptic Membrane, Regulation of G-Protein Coupled Receptor Protein Signaling, Positive Regulation of Endopeptidase Activity, Regulation of Carbohydrate Metabolic Process, Platelet-derived growth Factor Receptor Signaling, Negative Regulation of Transporter Activity, Regulation of long-term Neuronal Synaptic Plasticity