VDAC1 抗体 (AA 85-190)
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- 抗原 See all VDAC1 抗体
- VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))
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抗原表位
- AA 85-190
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适用
- 人, 大鼠
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宿主
- 兔
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克隆类型
- 多克隆
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标记
- This VDAC1 antibody is un-conjugated
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应用范围
- Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
- 特异性
- May detect VDAC2 due to sequence similarity
- 交叉反应
- 人, 大鼠
- 预测反应
- Mouse,Dog,Cow,Sheep,Pig,Horse,Rabbit
- 纯化方法
- Purified by Protein A.
- 免疫原
- KLH conjugated synthetic peptide derived from human VDAC1
- 亚型
- IgG
- Top Product
- Discover our top product VDAC1 Primary Antibody
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- 应用备注
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WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200 - 限制
- 仅限研究用
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- 状态
- Liquid
- 浓度
- 1 μg/μL
- 缓冲液
- 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
- 储存液
- ProClin
- 注意事项
- This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
- 储存条件
- 4 °C,-20 °C
- 储存方法
- Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
- 有效期
- 12 months
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Penehyclidine hydrochloride prevents anoxia/reoxygenation injury and induces H9c2 cardiomyocyte apoptosis via a mitochondrial pathway." in: European journal of pharmacology, Vol. 797, pp. 115-123, (2017) (PubMed).
: "Resveratrol improves mitochondrial function in the remnant kidney from 5/6 nephrectomized rats." in: Acta histochemica, Vol. 119, Issue 4, pp. 392-399, (2017) (PubMed).
: "Penehyclidine hydrochloride post-conditioning reduces ischemia/reperfusion-induced cardiomyocyte apoptosis in rats." in: Experimental and therapeutic medicine, Vol. 14, Issue 5, pp. 4272-4278, (2017) (PubMed).
: "Proteomic identification of mitochondrial targets involved in andrographolide sodium bisulfite-induced nephrotoxicity in a rat model." in: Environmental toxicology and pharmacology, Vol. 40, Issue 2, pp. 592-9, (2015) (PubMed).
: "Abnormal interaction of VDAC1 with amyloid beta and phosphorylated tau causes mitochondrial dysfunction in Alzheimer's disease." in: Human molecular genetics, Vol. 21, Issue 23, pp. 5131-46, (2012) (PubMed).
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Penehyclidine hydrochloride prevents anoxia/reoxygenation injury and induces H9c2 cardiomyocyte apoptosis via a mitochondrial pathway." in: European journal of pharmacology, Vol. 797, pp. 115-123, (2017) (PubMed).
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- 抗原
- VDAC1 (Voltage-Dependent Anion Channel 1 (VDAC1))
- 别名
- VDAC (VDAC1 产品)
- 别名
- vdac1 antibody, VDAC1 antibody, 5076 antibody, ARABIDOPSIS THALIANA VOLTAGE DEPENDENT ANION CHANNEL 1 antibody, ATVDAC1 antibody, T22N4.9 antibody, T22N4_9 antibody, voltage dependent anion channel 1 antibody, PORIN antibody, VDAC-1 antibody, AL033343 antibody, Vdac5 antibody, fa13f11 antibody, wu:fa13f11 antibody, zgc:85830 antibody, voltage-dependent anion channel 1 S homeolog antibody, voltage-dependent anion channel 1 antibody, voltage dependent anion channel 1 antibody, vdac1.S antibody, vdac1 antibody, VDAC1 antibody, Vdac1 antibody
- 背景
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Synonyms: PORIN, VDAC-1, Voltage-dependent anion-selective channel protein 1, hVDAC1, Outer mitochondrial membrane protein porin 1, Plasmalemmal porin, Porin 31HL, Porin 31HM, VDAC1, VDAC
Background: Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules, in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. May participate in the formation of the permeability transition pore complex (PTPC) responsible for the release of mitochondrial products that triggers apoptosis.
- 基因ID
- 7416
- UniProt
- P21796
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